Ratiometric;
Fluorescent probe;
Hypochlorite;
Phenothiazine;
LARGE STOKES SHIFT;
D O I:
10.1016/j.jphotochem.2021.113343
中图分类号:
O64 [物理化学(理论化学)、化学物理学];
学科分类号:
070304 ;
081704 ;
摘要:
Hypochlorite (ClO- ), as a typical weak acidic ROS, is mainly endogenously produced by myeloperoxidase (MPO) catalyzing hydrogen peroxide (H2O2) and chloride ion (Cl- ) in leukocytes. Imbalance of hypochlorite concentration will not only cause biomolecular oxidation in organism, but also are correlated with a variety of physiological diseases. In this study, a novel ratiometric fluorescence probe PHPQ for detecting ClO- by incorporating the phenothiazine moiety into the HPQ fluorophore was designed and synthesized. The probe PHPQ was shown to be capable of selectively and sensitively monitoring ClO- in a fine ratiometric manner. It also displayed the merits of large blue-shift (98 nm), rapid response (30 s), excellent sensitivity (15 nM) and significant fluorescence ratiometric variations (253-fold). Moreover, PHPQ was successfully utilized for bioimaging exogenous/endogenous ClO- in living cells (MGC-803 and RAW264.7) and in zebrafish.
机构:
Shandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Shandong, Peoples R China
Sun Yat Sen Univ, Sch Chem, Guangzhou 510220, Guangdong, Peoples R ChinaShandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Shandong, Peoples R China
Zhang, Li-Jie
Zhao, Xuan
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Univ, Sch Life Sci, Inst Dev Biol, Jinan 250100, Shandong, Peoples R ChinaShandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Shandong, Peoples R China
Zhao, Xuan
Yang, Di
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Shandong, Peoples R ChinaShandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Shandong, Peoples R China
Yang, Di
Jia, Zhen-Zhen
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h-index: 0
机构:
Shandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Shandong, Peoples R ChinaShandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Shandong, Peoples R China
Jia, Zhen-Zhen
Han, Xiao
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h-index: 0
机构:
Shandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Shandong, Peoples R ChinaShandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Shandong, Peoples R China
Han, Xiao
Sun, Lin-Quan
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h-index: 0
机构:
Shandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Shandong, Peoples R ChinaShandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Shandong, Peoples R China
Sun, Lin-Quan
Yu, Li-Li
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h-index: 0
机构:
Shandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Shandong, Peoples R ChinaShandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Shandong, Peoples R China
Yu, Li-Li
Liu, Jin-Ting
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Shandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Shandong, Peoples R ChinaShandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Shandong, Peoples R China
Liu, Jin-Ting
He, Xiao-Dong
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h-index: 0
机构:
Shandong Univ, Sch Publ Hlth, Dept Phys & Chem Inspect, Jinan 250012, Shandong, Peoples R ChinaShandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Shandong, Peoples R China
He, Xiao-Dong
Miao, Jun-Ying
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h-index: 0
机构:
Shandong Univ, Sch Life Sci, Inst Dev Biol, Jinan 250100, Shandong, Peoples R ChinaShandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Shandong, Peoples R China
Miao, Jun-Ying
Zhao, Bao-Xiang
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h-index: 0
机构:
Shandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Shandong, Peoples R ChinaShandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Shandong, Peoples R China
Zhao, Bao-Xiang
SENSORS AND ACTUATORS B-CHEMICAL,
2018,
276
: 8
-
12
机构:
Shandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Peoples R ChinaShandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Peoples R China
Yuan, Qiong
Zhao, Zhi-Min
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Univ, Sch Life Sci, Inst Dev Biol, Jinan 250100, Peoples R ChinaShandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Peoples R China
Zhao, Zhi-Min
Zhang, Yan-Ru
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Peoples R ChinaShandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Peoples R China
Zhang, Yan-Ru
Su, Le
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Univ, Sch Life Sci, Inst Dev Biol, Jinan 250100, Peoples R ChinaShandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Peoples R China
Su, Le
Miao, Jun-Ying
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Univ, Sch Life Sci, Inst Dev Biol, Jinan 250100, Peoples R ChinaShandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Peoples R China
Miao, Jun-Ying
Zhao, Bao-Xiang
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Peoples R ChinaShandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Peoples R China
机构:
E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China
E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R ChinaE China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China
Wang, Xuzhe
Zhou, Li
论文数: 0引用数: 0
h-index: 0
机构:
E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R ChinaE China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China
Zhou, Li
Qiang, Fei
论文数: 0引用数: 0
h-index: 0
机构:
E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China
E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R ChinaE China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China
Qiang, Fei
Wang, Feiyi
论文数: 0引用数: 0
h-index: 0
机构:
E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China
E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R ChinaE China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China
Wang, Feiyi
Wang, Rui
论文数: 0引用数: 0
h-index: 0
机构:
E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R ChinaE China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China
Wang, Rui
Zhao, Chunchang
论文数: 0引用数: 0
h-index: 0
机构:
E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China
E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R ChinaE China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China