Development of a BODIPY-based ratiometric fluorescent probe for hypochlorous acid and its application in living cells

被引：52

作者：

Wang, Xuzhe ^{[1
,2
]}

Zhou, Li ^{[3
]}

Qiang, Fei ^{[1
,2
]}

Wang, Feiyi ^{[1
,2
]}

Wang, Rui ^{[3
]}

Zhao, Chunchang ^{[1
,2
]}

机构：

[1] E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China

[2] E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

[3] E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

来源：

ANALYTICA CHIMICA ACTA | 2016年 / 911卷

基金：

美国国家科学基金会;

关键词：

Ratiometric detection; Fluorescent probe; Hypochlorous acid; High selectivity; pH-independency; SELECTIVE DETECTION; TURN-ON; MYELOPEROXIDASE; OXIDATION; DESIGN; STRATEGY; SENSOR; SHIFT; HCLO; RED;

D O I：

10.1016/j.aca.2016.01.022

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A BODIPY-based ratiometric fluorescent probe for HOCl has been designed based on the transduction of thioether to sulfoxide function. This probe features a marked absorption and emission blue-shift upon the HOCl-promoted rapid transduction, enabling the highly selective and ratiometric detection. In addition, the probe works excellently within a wide pH range of 4-10, addressing the existing pH dependency issue. Living cells studies demonstrate that the probe is cell membrane permeable and can be employed successfully to image endogenous HOCl generation in macrophage cells. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：114 / 120

页数：7

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