A lysosome-targeted ratiometric fluorescent probe for detection of hypochlorous acid in living cells

被引：62

作者：

Yuan, Qiong ^{[1
]}

Zhao, Zhi-Min ^{[2
]}

Zhang, Yan-Ru ^{[1
]}

Su, Le ^{[2
]}

Miao, Jun-Ying ^{[2
]}

Zhao, Bao-Xiang ^{[1
]}

机构：

[1] Shandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Peoples R China

[2] Shandong Univ, Sch Life Sci, Inst Dev Biol, Jinan 250100, Peoples R China

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2017年 / 247卷

关键词：

Ratiometric; Fluorescent probe; Forster resonance energy transfer; Hypochlorous acid; Bioimaging; BOND ENERGY-TRANSFER; RECENT PROGRESS; TURN-ON; BIOIMAGING APPLICATIONS; BORON DIPYRROMETHENE; GENERATED OXIDANTS; FRET PLATFORM; CANCER-CELLS; LIVE CELLS; TAP WATER;

D O I：

10.1016/j.snb.2017.03.049

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A ratiometric fluorescent probe (DICX) based on Forster resonance energy transfer (FRET) system for hypochlorous acid (HOCl) was developed, in which coumarin moiety was connected to rhodamine by monothio-bishydrazide linker. DICX could fast respond to HOCl under acidic condition and showed high selectivity and sensitivity toward HOCl over other reactive oxygen species, reactive nitrogen species, and ions. The FRET energy transfer efficiency is very high (93.75%). Moreover, DICX could target lysosome and could be suitable for sensing exogenous and endogenous HOCl in living cells. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：736 / 741

页数：6

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