A tool to determine the specificity of antisense oligonucleotide

被引：0

作者：

Huang, YC ^{[1
]}

Chao, YC ^{[1
]}

Lin, SB ^{[1
]}

Tsai, HK ^{[1
]}

Chang, CF ^{[1
]}

Lee, SA ^{[1
]}

Kao, CY ^{[1
]}

机构：

[1] Natl Taiwan Univ, Dept Comp Sci & Informat Engn, Taipei, Taiwan

来源：

METMBS '04: PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON MATHEMATICS AND ENGINEERING TECHNIQUES IN MEDICINE AND BIOLOGICAL SCIENCES | 2004年

关键词：

antisense; nucleic acid drug; nearest-neighbor Tm;

D O I：

暂无

中图分类号：

TP18 [人工智能理论];

学科分类号：

081104 ; 0812 ; 0835 ; 1405 ;

摘要：

It has been a practical problem for antisense researchers to select antisense oligonucleotides (asON) with a high degree of specificity, which means no or minimum cross-hybridization to other expressed genes. This paper provides a computer program, UniAntisense, which simulates hybridization of the candidate asON with every sequence in a specified UniGene database and calculates melting temperature and free energy for each hybridizable sequence to facilitate the process of selecting optimal asON.

引用

页码：447 / 450

页数：4

共 50 条

[41] Antisense oligonucleotide technologies in drug discovery
Aboul-Fadl, Tarek
EXPERT OPINION ON DRUG DISCOVERY, 2006, 1 (04) : 285 - 288
[42] Chemical modified antisense oligonucleotide and siRNA
Zhang, Li-He
Yang, Zhen-Jun
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 243
[43] Antisense oligonucleotide therapeutics for human leukemia
Gewirtz, AM
CRITICAL REVIEWS IN ONCOGENESIS, 1997, 8 (01): : 93 - 109
[44] Antisense oligonucleotide hope for childhood epilepsies
Fyfe I.
Nature Reviews Neurology, 2020, 16 (3) : 128 - 128
[45] Molecular medicine - Antisense oligonucleotide therapy
Askari, FK
McDonnell, WM
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (05): : 316 - 318
[46] Antisense oligonucleotide slows glioma growth
Caroline Barranco
Nature Reviews Drug Discovery, 2023, 22 : 445 - 445
[47] SPLICE MUTATIONS - ANTISENSE OLIGONUCLEOTIDE MODULATION
Kerem, Batsheva
PEDIATRIC PULMONOLOGY, 2018, 53 : 113 - 114
[48] Antisense oligonucleotide therapy for urologic tumors
Ingo Kausch
Andreas Böhle
Current Urology Reports, 2003, 4 (1) : 60 - 69
[49] Acetal oligonucleotide conjugates in antisense strategy
Matysiak, S
Frank, R
Pfleiderer, W
NUCLEOSIDES & NUCLEOTIDES, 1997, 16 (5-6): : 855 - 861
[50] Antisense oligonucleotide therapy of hepadnavirus infection
Offensperger, WB
Thoma, C
Moradpour, D
von Weizsäcker, F
Offensperger, S
Blum, HE
ANTISENSE TECHNOLOGY, PT B, 2000, 314 : 524 - 536

← 1 2 3 4 5 →