A tool to determine the specificity of antisense oligonucleotide

被引：0
|
作者：
Huang, YC [1 ]
Chao, YC [1 ]
Lin, SB [1 ]
Tsai, HK [1 ]
Chang, CF [1 ]
Lee, SA [1 ]
Kao, CY [1 ]
机构：
[1] Natl Taiwan Univ, Dept Comp Sci & Informat Engn, Taipei, Taiwan
来源：
METMBS '04: PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON MATHEMATICS AND ENGINEERING TECHNIQUES IN MEDICINE AND BIOLOGICAL SCIENCES | 2004年
关键词：
antisense; nucleic acid drug; nearest-neighbor Tm;
D O I：
暂无
中图分类号：
TP18 [人工智能理论];
学科分类号：
081104 ; 0812 ; 0835 ; 1405 ;
摘要：
It has been a practical problem for antisense researchers to select antisense oligonucleotides (asON) with a high degree of specificity, which means no or minimum cross-hybridization to other expressed genes. This paper provides a computer program, UniAntisense, which simulates hybridization of the candidate asON with every sequence in a specified UniGene database and calculates melting temperature and free energy for each hybridizable sequence to facilitate the process of selecting optimal asON.
引用
收藏
页码：447 / 450
页数：4
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