A tool to determine the specificity of antisense oligonucleotide

被引：0

作者：

Huang, YC ^{[1
]}

Chao, YC ^{[1
]}

Lin, SB ^{[1
]}

Tsai, HK ^{[1
]}

Chang, CF ^{[1
]}

Lee, SA ^{[1
]}

Kao, CY ^{[1
]}

机构：

[1] Natl Taiwan Univ, Dept Comp Sci & Informat Engn, Taipei, Taiwan

来源：

METMBS '04: PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON MATHEMATICS AND ENGINEERING TECHNIQUES IN MEDICINE AND BIOLOGICAL SCIENCES | 2004年

关键词：

antisense; nucleic acid drug; nearest-neighbor Tm;

D O I：

暂无

中图分类号：

TP18 [人工智能理论];

学科分类号：

081104 ; 0812 ; 0835 ; 1405 ;

摘要：

It has been a practical problem for antisense researchers to select antisense oligonucleotides (asON) with a high degree of specificity, which means no or minimum cross-hybridization to other expressed genes. This paper provides a computer program, UniAntisense, which simulates hybridization of the candidate asON with every sequence in a specified UniGene database and calculates melting temperature and free energy for each hybridizable sequence to facilitate the process of selecting optimal asON.

引用

页码：447 / 450

页数：4

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