Pulmonary toxicity associated with nitric oxide in term infants with severe respiratory failure

被引：28
|
作者：
Hallman, M
Bry, K
Turbow, R
Waffarn, F
Lappalainen, U
机构：
[1] Univ Oulu, Dept Pediat, SF-90220 Oulu, Finland
[2] Univ Calif Irvine, Irvine Med Ctr, Dept Pediat, Div Neonatal Med, Orange, CA 92668 USA
[3] Vanderbilt Univ, Dept Pediat, Div Neonatal Med, Nashville, TN USA
[4] Sierra Vista Reg Med Ctr, San Luis Obispo, CA USA
来源：
JOURNAL OF PEDIATRICS | 1998年 / 132卷 / 05期
关键词：
D O I：
10.1016/S0022-3476(98)70312-9
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
We prospectively analyzed airway specimens from 24 newborn infants. Inhaled nitric oxide (less than or equal to 20 ppm for 1 to 4 days to 12 infants) did not affect the concentrations of the lipid peroxidation product, the surface activity, or the cytokines (interleukin-l, granulocyte-macrophage colony-stimulating factor, interleukin-l receptor antagonist). Nitrotyrosine was detected after 10 days of life in the two infants requiring prolonged ventilation, suggesting toxicity of endogenous nitric oxide.
引用
收藏
页码：827 / 829
页数：3
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