Pulmonary toxicity associated with nitric oxide in term infants with severe respiratory failure

被引：28

作者：

Hallman, M

Bry, K

Turbow, R

Waffarn, F

Lappalainen, U

机构：

[1] Univ Oulu, Dept Pediat, SF-90220 Oulu, Finland

[2] Univ Calif Irvine, Irvine Med Ctr, Dept Pediat, Div Neonatal Med, Orange, CA 92668 USA

[3] Vanderbilt Univ, Dept Pediat, Div Neonatal Med, Nashville, TN USA

[4] Sierra Vista Reg Med Ctr, San Luis Obispo, CA USA

来源：

JOURNAL OF PEDIATRICS | 1998年 / 132卷 / 05期

关键词：

D O I：

10.1016/S0022-3476(98)70312-9

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We prospectively analyzed airway specimens from 24 newborn infants. Inhaled nitric oxide (less than or equal to 20 ppm for 1 to 4 days to 12 infants) did not affect the concentrations of the lipid peroxidation product, the surface activity, or the cytokines (interleukin-l, granulocyte-macrophage colony-stimulating factor, interleukin-l receptor antagonist). Nitrotyrosine was detected after 10 days of life in the two infants requiring prolonged ventilation, suggesting toxicity of endogenous nitric oxide.

引用

页码：827 / 829

页数：3

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