Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis

被引：16

作者：

Kim, Chung Sub ^{[1
]}

Subedi, Lalita ^{[2
,3
]}

Kwon, Oh Kil ^{[1
]}

Kim, Sun Yeou ^{[2
,3
]}

Yeo, Eui-Ju ^{[4
]}

Choi, Sang Un ^{[5
]}

Lee, Kang Ro ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Pharm, Nat Prod Lab, Suwon 16419, South Korea

[2] Gachon Univ, Gachon Inst Pharmaceut Sci, Inchon 21936, South Korea

[3] Gachon Univ, Coll Pharm, Inchon 21936, South Korea

[4] Gachon Univ, Coll Med, Dept Biochem, Inchon 51936, South Korea

[5] Korea Res Inst Chem Technol, Daejeon 34114, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

Chaenomeles sinensis; Biphenyl compounds; Cytotoxicity; Anti-inflammation; NGF-potentiation; SORBUS-AUCUPARIA; IN-VITRO; FRUITS; PHYTOALEXINS; SAPWOOD;

D O I：

10.1016/j.bmcl.2015.12.004

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Investigation of the MeOH extract of Chaenomeles sinensis twigs resulted in the isolation of seven biphenyl compounds (1-7) including a new compound, chaenomin (1). The chemical structures of the isolated compounds were elucidated by extensive NMR data (H-1 and C-13 NMR, H-1-H-1 COSY, HSQC and HMBC), specific optical rotation, and chemical reaction. Compounds 2 and 6 showed potent cytotoxic activities against four cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15), and compound 7 exhibited potent anti-neuroinflammatory and NGF-potentiating activity. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：351 / 354

页数：4

共 50 条

[41] Two New Terpenoids From the Fruits of Chaenomeles sinensis (Thouin) Koehne
Li, Meng
Zhang, Zhi-guang
Shi, Jing-ya
Li, Ya-ge
Zhang, Jing-ke
Ying, Yang
Deng, Xiao-yan
Zheng, Xiao-ke
Feng, Wei-sheng
NATURAL PRODUCT COMMUNICATIONS, 2021, 16 (02)
[42] Optimization of ultrasonic-assisted extraction of phenolic compounds from Chinese quince (Chaenomeles sinensis) by response surface methodology
Hui Teng
In Hee Jo
Yong Hee Choi
Journal of the Korean Society for Applied Biological Chemistry, 2010, 53 : 618 - 625
[43] Purification and Characterization of a Lectin from Chinese Quince (Chaenomeles sinensis) Fruit
Ishiwari, Atsuya
Akutsu, Tomoko
Ikegaya, Hiroshi
Sakurada, Koichi
JOURNAL OF PLANT BIOCHEMISTRY AND BIOTECHNOLOGY, 2010, 19 (02) : 243 - 245
[44] Optimization of Ultrasonic-assisted Extraction of Phenolic Compounds from Chinese Quince (Chaenomeles sinensis) by Response Surface Methodology
Teng, Hui
Jo, In Hee
Choi, Yong Hee
JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, 2010, 53 (05): : 618 - 625
[45] EXTRACTION, ISOLATION AND CHARACTERIZATION OF BIOACTIVE COMPOUNDS FROM PLANTS' EXTRACTS
Sasidharan, S.
Chen, Y.
Saravanan, D.
Sundram, K. M.
Latha, L. Yoga
AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES, 2011, 8 (01) : 1 - 10
[46] Isolation and identification of bioactive compounds from licorice (Glycyrrhiza glabra).
Vastano, BC
Rafi, MM
DiPaola, RS
Ho, CT
Zhu, NQ
Rosen, RT
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 221 : U38 - U38
[47] Isolation and characterization of compounds from bioactive extracts of monarda citreodora
Dodson, SL
Belofsky, G
Wallace, D
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2002, 223 : U268 - U268
[48] Isolation of Bioactive Compounds from the Fermented Seeds of Pentaclethra macrophylla
Jecinta Ndiombueze Anowu
Abubakar Babando Aliyu
Hamisu Ibrahim
Adebayo Ojo Oyewale
Chemistry of Natural Compounds, 2021, 57 : 746 - 748
[49] ANTIDIABETIC ACTIVITY AND ISOLATION OF BIOACTIVE COMPOUNDS FROM HYDROLEA ZEYLANICA
Vijay, Borkar S.
Kumaran, Senthil K.
Kumar, Senthil K. L.
Hemant, Gangurde H.
Mayur, Chordiya A.
INDONESIAN JOURNAL OF PHARMACY, 2015, 26 (04): : 185 - 191
[50] Isolation and characterization of bioactive compounds from the bark of Litsea costalis
Hosseinzadeh, Masoumeh
Mohamad, Jamaludin
Khalilzadeh, Mohammad A.
Zardoost, Mohammad Reza
Haak, Jeannie
Rajabi, Mehdi
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2013, 128 : 85 - 91

← 1 2 3 4 5 →