Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis

被引：16

作者：

Kim, Chung Sub ^{[1
]}

Subedi, Lalita ^{[2
,3
]}

Kwon, Oh Kil ^{[1
]}

Kim, Sun Yeou ^{[2
,3
]}

Yeo, Eui-Ju ^{[4
]}

Choi, Sang Un ^{[5
]}

Lee, Kang Ro ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Pharm, Nat Prod Lab, Suwon 16419, South Korea

[2] Gachon Univ, Gachon Inst Pharmaceut Sci, Inchon 21936, South Korea

[3] Gachon Univ, Coll Pharm, Inchon 21936, South Korea

[4] Gachon Univ, Coll Med, Dept Biochem, Inchon 51936, South Korea

[5] Korea Res Inst Chem Technol, Daejeon 34114, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

Chaenomeles sinensis; Biphenyl compounds; Cytotoxicity; Anti-inflammation; NGF-potentiation; SORBUS-AUCUPARIA; IN-VITRO; FRUITS; PHYTOALEXINS; SAPWOOD;

D O I：

10.1016/j.bmcl.2015.12.004

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Investigation of the MeOH extract of Chaenomeles sinensis twigs resulted in the isolation of seven biphenyl compounds (1-7) including a new compound, chaenomin (1). The chemical structures of the isolated compounds were elucidated by extensive NMR data (H-1 and C-13 NMR, H-1-H-1 COSY, HSQC and HMBC), specific optical rotation, and chemical reaction. Compounds 2 and 6 showed potent cytotoxic activities against four cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15), and compound 7 exhibited potent anti-neuroinflammatory and NGF-potentiating activity. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：351 / 354

页数：4

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