Design of potent and selective cathepsin K inhibitors which span the active site.

被引：0
|
作者：
Thompson, SK
Halbert, SM
Michaud, E
Bossard, MJ
Tomaszek, TA
Levy, MA
Meek, TD
Zhao, B
Smith, WW
Janson, CA
McQueney, MS
AbdelMeguid, SS
Briand, J
Sarkar, SK
Huddleston, MJ
Ijames, CF
Carr, SA
DesJarlais, RL
Shu, A
Garnes, K
Heys, JR
Zembryki, D
LeeRykaczewski, LV
James, IE
Lark, M
Bradbeer, JN
Drake, FH
Gowen, M
Veber, DF
机构：
[1] SMITHKLINE BEECHAM PHARMACEUT,DEPT MED CHEM,KING OF PRUSSIA,PA 19406
[2] SMITHKLINE BEECHAM PHARMACEUT,DEPT MOL RECOGNIT,KING OF PRUSSIA,PA 19406
[3] SMITHKLINE BEECHAM PHARMACEUT,DEPT MACROMOL SCI,KING OF PRUSSIA,PA 19406
[4] SMITHKLINE BEECHAM PHARMACEUT,DEPT PHYS & STRUCT CHEM,KING OF PRUSSIA,PA 19406
[5] SMITHKLINE BEECHAM PHARMACEUT,DEPT RADIOCHEM,KING OF PRUSSIA,PA 19406
[6] SMITHKLINE BEECHAM PHARMACEUT,DEPT CELLULAR BIOCHEM,KING OF PRUSSIA,PA 19406
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 1997年 / 214卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
引用
收藏
页码：279 / MEDI
页数：1
相关论文
共 50 条
  • [31] In Search of Selective Inhibitors of Cysteine Protease, Cathepsin K
    Ewa Wieczerzak
    Piotr Drabik
    Magnus Abrahamson
    Anders Grubb
    International Journal of Peptide Research and Therapeutics, 2005, 11 : 203 - 209
  • [32] Design of Potent and Selective Cathepsin G Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold
    Swedberg, Joaidm E.
    Li, Choi Yi
    de Veer, Simon J.
    Wang, Conan K.
    Craik, David J.
    JOURNAL OF MEDICINAL CHEMISTRY, 2017, 60 (02) : 658 - 667
  • [33] Arylaminoethyl carbamates as a novel series of potent and selective cathepsin S inhibitors
    Tully, David C.
    Liu, Hong
    Chatterjee, Arnab K.
    Alper, Phil B.
    Williams, Jennifer A.
    Roberts, Michael J.
    Mutnick, Daniel
    Woodmansee, David H.
    Hollenbeck, Thomas
    Gordon, Perry
    Chang, Jonathan
    Tuntland, Tove
    Tumanut, Christine
    Li, Jun
    Harris, Jennifer L.
    Karanewsky, Donald S.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (19) : 5107 - 5111
  • [34] Peptidomimetic 2-cyanopyrrolidines as potent selective cathepsin L inhibitors
    Yadav, Mange R.
    Shinde, Anil K.
    Chouhan, Bishram S.
    Giridhar, Rajani
    Menard, Robert
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2008, 23 (02) : 190 - 197
  • [35] PEPTIDYL ALDEHYDE DERIVATIVES AS POTENT AND SELECTIVE INHIBITORS OF CATHEPSIN-L
    WOO, JT
    SIGEIZUMI, S
    YAMAGUCHI, K
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (14) : 1501 - 1504
  • [36] Discovery of highly potent and selective covalent reversible cathepsin S inhibitors
    Haap, Wolfgang
    Hartmann, Guido
    Sanchez, Ruben Alvarez
    Anselm, Lilli
    Banner, David W.
    Ecabert, Robert
    Grether, Uwe
    Kuehne, Holger
    Kuhn, Bernd
    Luebbers, Thomas
    Peters, Jens-Uwe
    Plancher, Jean-Marc
    Rufer, Arne
    Spinnler, Beat
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
  • [37] Design of fast enzymes by optimizing interaction potential in active site.
    Zhou, HX
    BIOPHYSICAL JOURNAL, 1997, 72 (02) : WP427 - WP427
  • [38] MEDI 69-Investigation of ketone warheads as alternatives to the nitrile for preparation of potent and selective cathepsin k inhibitors
    Boyd, Michael J.
    Crane, Sheldon N.
    Robichaud, Joel
    Scheigetz, John
    Black, Cameron
    Chauret, Nathalie
    Wang, Qingping
    Masse, Frederic
    Oballa, Renata
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, 235
  • [39] Cathepsin B: Active site mapping with peptidic substrates and inhibitors
    Schmitz, Janina
    Gilberg, Erik
    Loeser, Reik
    Bajorath, Juergen
    Bartz, Ulrike
    Guetschow, Michael
    BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 27 (01) : 1 - 15
  • [40] Novel and potent cyclic cyanamide-based cathepsin K inhibitors
    Deaton, DN
    Hassell, AM
    McFadyen, RB
    Miller, AB
    Miller, LR
    Shewchuk, LM
    Tavares, FX
    Willard, DH
    Wright, LL
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (07) : 1815 - 1819
12345