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- [41] Identification of a potent and selective non-basic cathepsin K inhibitorBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (07) : 1985 - 1989Li, CSDeschenes, DDesmarais, SFalgueyret, JPGauthier, JYKimmel, DBLéger, SMassé, FMcGrath, MEMcKay, DJPercival, MDRiendeau, DRodan, SBThérien, MTruong, VLWesolowski, GZamboni, RBlack, WC
- [42] Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug designJOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (26) : 4524 - 4534Greenspan, PDClark, KLTommasi, RACowen, SDMcQuire, LWFarley, DLvan Duzer, JHGoldberg, RLZhou, HHDu, ZMFitt, JJCoppa, DEFang, ZMacchia, WZhu, LJCapparelli, MPGoldstein, RWigg, AMDoughty, JRBohacek, RSKnap, AK
- [43] DESIGN AND SYNTHESIS OF POTENT, SELECTIVE, AND ORALLY ACTIVE FLUORINE-CONTAINING RENIN INHIBITORSJOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (01) : 2 - 14DOHERTY, AMSIRCAR, IKORNBERG, BEQUIN, JWINTERS, RTKALTENBRONN, JSTAYLOR, MDBATLEY, BLRAPUNDALO, SRRYAN, MJPAINCHAUD, CA
- [44] IDENTIFICATION OF EXOSITE INHIBITORS OF CATHEPSIN K AS SELECTIVE COLLAGENASE BLOCKERSOSTEOPOROSIS INTERNATIONAL, 2012, 23 : S600 - S600Du, Kevin XinKaleta, JadwigaSharma, VidhuNicholls, AllisonPfeifer, TomBromme, Dieter
- [45] Strategies for the design of potent and selective kinase inhibitorsCURRENT PHARMACEUTICAL DESIGN, 2005, 11 (14) : 1845 - 1863McInnes, CFischer, PM
- [46] Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin KJOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (24) : 7520 - 7534Palmer, JTBryant, CWang, DXDavis, DESetti, ELRydzewski, RMVenkatraman, STian, ZQBurrill, LCMendonca, RVSpringman, EMcCarter, JChung, TCheung, HJanc, JWMcGrath, MSomoza, JREnriquez, PYu, ZWStrickley, RMLiu, LVenuti, MCPercival, MDFalgueyret, JPPrasit, POballa, RRiendeau, DYoung, RNWesolowski, GRodan, SBJohnson, CKimmel, DBRodan, G
- [47] Use of X-ray co-crystal structures and molecular modeling to design potent and selective non-peptide inhibitors of cathepsin KJOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (35) : 9114 - 9115DesJarlais, RLYamashita, DSOh, HJUzinskas, INErhard, KFAllen, ACHaltiwanger, RCZhao, BGSmith, WWAbdel-Meguid, SSD'Alessio, KJanson, CAMcQueney, MSTomaszek, TALevy, MAVeber, DF
- [48] Design and Synthesis of Potent, Selective Inhibitors of MatriptaseACS MEDICINAL CHEMISTRY LETTERS, 2012, 3 (07): : 530 - 534Colombo, EloicDesilets, AntoineDuchene, DominicChagnon, FelixNajmanovich, RafaelLeduc, RichardMarsault, Eric
- [49] Design and synthesis of dipeptide nitriles as reversible and potent cathepsin S inhibitorsJOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (25) : 5471 - 5482Ward, YDThomson, DSFrye, LLCywin, CLMorwick, TEmmanuel, MJZindell, RMcNeil, DBekkali, YGiradot, MHrapchak, MDe Turi, MCrane, KWhite, DPav, SWang, YHao, MHGrygon, CALabadia, MEFreeman, DMDavidson, WHopkins, JLBrown, MLSpero, DM
- [50] Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C (vol 19, pg 5392, 2009)BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (22) : 6481 - 6481Guay, DanielBeaulieu, ChristianReddy, T. JagadeeswarZamboni, RobertMethot, NathalieRubin, JoelEthier, DianePercival, M. David