Synthesis of cyclic dipeptides by ring-closing metathesis

被引：0

作者：

Reichwein, JF ^{[1
]}

Liskamp, RMJ ^{[1
]}

机构：

[1] Univ Utrecht, Inst Pharmaceut Sci, Dept Med Chem, NL-3508 TB Utrecht, Netherlands

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2000年 / 2000卷 / 12期

关键词：

ring closure; metathesis; peptides; peptidomimetics; cyclization; dienes;

D O I：

10.1002/1099-0690(200006)2000:12<2335::AID-EJOC2335>3.0.CO;2-C

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several cyclic dipeptides (4a-g and 9a-c) have been synthesized by "amide-to-amide" cyclization of 2a-g and 8a-c, respectively, by means of ring-closing metathesis employing the Grubbs ruthenium catalyst. The influence of additives as well as the length of the amide substituent were studied. Best yields were obtained by cyclization in solution with either lithium fluoroacetate or alpha,alpha-dichlorotoluene as an additive.

引用

页码：2335 / 2344

页数：10

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