A ring-closing metathesis approach for the synthesis of (±)-pregabalin

被引：4
|
作者：
Bobade, Vivek D. [1 ]
Mhaske, Pravin C. [1 ]
Vadgaonkar, Kamlesh S. [1 ]
Shelke, Shivaji H. [1 ]
机构：
[1] HPT Arts & RYK Sci Coll, Postgrad Dept Chem, Nasik 422005, India
来源：
MONATSHEFTE FUR CHEMIE | 2012年 / 143卷 / 05期
关键词：
Pregabalin; Mannich-type reaction; Ring-closing metathesis; Reduction; ENANTIOSELECTIVE SYNTHESIS; POTENT; ACIDS; PAIN;
D O I：
10.1007/s00706-011-0654-8
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Efficient utilization of a Mannich-type reaction and the ring-closing metathesis (RCM) approach that leads to a convenient synthesis of 3-(aminomethyl)-5-methylhexanoic acid (pregabalin) is described.
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页码：847 / 851
页数：5
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