Efficient C-S Bond Formation by Direct Functionalization of C(sp3)-H Bond Adjacent to Heteroatoms under Metal-Free Conditions

被引：23
|
作者：
Zhao, Feng [1 ,2 ]
Tan, Qi [1 ]
Wang, Dahan [2 ]
Chen, Jinjin [2 ]
Deng, Guo-Jun [2 ,3 ]
机构：
[1] Hunan Univ Med, Key Lab Dong Med Hunan Prov, Sch Pharmaceut Sci, Huaihua 418000, Peoples R China
[2] Xiangtan Univ, Key Lab Environmentally Friendly Chem & Applicat, Key Lab Green Organ Synth & Applicat Hunan Prov, Minist Educ,Coll Chem, Xiangtan 411105, Peoples R China
[3] Chinese Acad Sci, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2019年 / 361卷 / 17期
基金：
中国国家自然科学基金;
关键词：
C(sp(3))-H functionalization; C-S bond formation; heteroatoms; sodium sulfinates; metal-free; CATALYZED REGIOSELECTIVE SULFENYLATION; CROSS-COUPLING REACTION; H BONDS; SULFONYL HYDRAZIDES; DIRECT THIOLATION; INDOLES; ETHERS; DISULFIDES; ARYLATION; OXIDANT;
D O I：
10.1002/adsc.201900666
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A simple and efficient method for the formation of C-S bond via direct functionalization of C(sp(3))-H bond adjacent to heteroatoms was described under metal-free conditions. In this work, stable and easily accessible sodium sulfinates were used as the thiolating agents to afford various aryl thioethers in moderate to excellent yields. Mechanistic explorations show that a radical pathyway is possibly involved during the transformations.
引用
收藏
页码：4075 / 4081
页数：7
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