Recent Development of Metal-Free Direct Asymmetric Functionalization of Benzylic C(sp3)-H Bond

被引：3
|
作者：
Jiang, Xin [1 ]
Wang, Sidun [1 ]
Guo, Guimin [1 ]
Lu, Beili [1 ]
机构：
[1] Fujian Agr & Forestry Univ, Coll Mat Engn, Fuzhou 350002, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 37卷 / 04期
基金：
中国国家自然科学基金;
关键词：
metal-free; benzylic position; C-H functionalization; organocatalysis; asymmetric synthesis; DEHYDROGENATIVE ALPHA-ALKYLATION; BETA-FUNCTIONALIZATION; SELECTIVE ACTIVATION; TERTIARY-AMINES; ALDEHYDES; STRATEGY; HETEROATOM; ANNULATION; OXIDATION; ARYLATION;
D O I：
10.6023/cjoc201610010
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Compounds containing aryl structures are important organic synthesis intermediates, which are widely present in a large family of natural products and bioactive molecules. In recent years, direct asymmetric functionalization of benzylic C(sp(3))-H bond for the efficient construction of arene and hetero-arene motifs with high stereoselectivity has drawn widespread concern from chemical community. Among the various strategies, small molecule-catalyzed metal-free functionalization of benzylic C(sp(3))-H bond represents a more challenging but promising transformations. This review is intended to summarize and discuss the most recent advances in this area.
引用
收藏
页码：841 / 857
页数：17
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