Discrete Element Modeling (DEM) based investigation of tribocharging in the pharmaceutical powders during hopper discharge

被引:12
|
作者
Mukherjee, Raj [1 ]
Sansare, Sameera [1 ]
Nagarajan, Venkatraman [1 ]
Chaudhuri, Bodhisattwa [1 ,2 ,3 ]
机构
[1] Univ Connecticut, Dept Pharmaceut Sci, Storrs, CT 06269 USA
[2] Univ Connecticut, Dept Chem & Biomol Engn, Storrs, CT 06269 USA
[3] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA
关键词
Tribocharging; Work function; Hopper flow; Discrete Element Modeling;
D O I
10.1016/j.ijpharm.2021.120284
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Triboelectric charging is defined as the phenomenon of charge transfer between two different material surfaces when they are brought into contact and separated. The focus of this research is the development of a Discrete Element Method (DEM) based simulation model to predict tribocharging during hopper discharge. Due to decreased particle-wall interactions and reduced particle wall contact times, net charges generated during hopper discharge are low. The simulation model confirmed this effect and was implemented to predict the triboelectric behavior of glass beads and MCC particles during hopper flow, along with the prediction of percent charged and uncharged particles. Approximately one-third of the particles were predicted to remain uncharged during the hopper discharge simulations for mono-dispersed particles, thus rendering a comparatively high amount of charge distribution into a small concentration of materials. The DEM model acted as a tool to predict charges that can be generated during hopper discharge at a specified geometry, with a potential to mitigate particle charging, when used for appropriate selection of hopper angles, and hopper wall materials.
引用
收藏
页数:8
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