Quantitative structure-activity relationship studies on some acyclouridine derivatives acting as anti-HIV-1 drugs

被引：15
|
作者：
Garg, R
Kurup, A
Gupta, SP
机构：
[1] BIRLA INST TECHNOL & SCI,DEPT CHEM,PILANI 333031,RAJASTHAN,INDIA
[2] BIRLA INST TECHNOL & SCI,DEPT PHARM,PILANI 333031,RAJASTHAN,INDIA
来源：
QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS | 1997年 / 16卷 / 01期
关键词：
quantitative structure-activity relationship; HIV-1; inhibitors; HEPT derivatives;
D O I：
10.1002/qsar.19970160104
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The anti-HIV-1 activity of some derivatives of 1-[2-hydroxyethoxy]-6-(phenylthio)thymine(HEPT) is analyzed in relation to their physicochemical and molecular properties. The activities of the compounds are found to be significantly correlated with hydrophobic constant 71 and the van der Waals volume V-w. The results are found to be useful in discussing the mechanism of drug-receptor interaction.
引用
收藏
页码：20 / 24
页数：5
相关论文
共 50 条
  • [21] Quantitative structure activity reiationship (QSAR) studies on anti-HIV-1 and cytotoxic arylpyrrolylsulfones
    Srivastava, AK
    Khan, AA
    Shakil, M
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2001, 78 (03) : 154 - 157
  • [22] STUDY ON ANTI-HIV ACTIVITY OF DIARYLANILINE DERIVATIVES USING QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP (QSAR)
    Arief, Ihsanul
    Armunanto, Ria
    Setiaji, Bambang
    INDONESIAN JOURNAL OF CHEMISTRY, 2013, 13 (02) : 129 - 135
  • [23] Comparative quantitative structure-activity relationship studies on anti-HIV drugs (vol 99, pg 3525, 1999)
    Garg, R
    Gupta, SP
    Gao, H
    Babu, MS
    Debnath, AK
    Hansch, C
    CHEMICAL REVIEWS, 2002, 102 (09) : 3213 - 3213
  • [24] Molecular Descriptors Family on Structure-Activity Relationships on anti-HIV-1 potencies of HEPT and TIBO derivatives
    Bolboacae, Sorana
    Jantschi, Lorentz
    INTEGRATING BIOMEDICAL INFORMATION: FROM E-CELL TO E-PATIENT, 2006, : 222 - +
  • [25] QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP (QSAR) IN CENTRALLY ACTING HYPOTENSIVE IMIDAZOLIDINE DERIVATIVES
    TIMMERMANS, PBMWM
    VANZWIETEN, PA
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1977, 297 : R34 - R34
  • [26] Quantitative structure-activity relationship study on some benzodiazepine derivatives as anti-Alzheimer agents
    Debnath, B
    Gayen, S
    Basu, A
    Srikanth, K
    Jha, T
    JOURNAL OF MOLECULAR MODELING, 2004, 10 (5-6) : 328 - 334
  • [27] Understanding the structure-activity relationship of betulinic acid derivatives as anti-HIV-1 agents by using 3D-QSAR and docking
    Ping Lan
    Wan-Na Chen
    Zhi-Jian Huang
    Ping-Hua Sun
    Wei-Min Chen
    Journal of Molecular Modeling, 2011, 17 : 1643 - 1659
  • [28] Understanding the structure-activity relationship of betulinic acid derivatives as anti-HIV-1 agents by using 3D-QSAR and docking
    Lan, Ping
    Chen, Wan-Na
    Huang, Zhi-Jian
    Sun, Ping-Hua
    Chen, Wei-Min
    JOURNAL OF MOLECULAR MODELING, 2011, 17 (07) : 1643 - 1659
  • [29] Structure-activity relationship study of flavone compounds with anti-HIV-1 integrase activity: A density functional theory study
    Lameira, J.
    Medeiros, I. G.
    Reis, M.
    Santos, A. S.
    Alves, C. N.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (21) : 7105 - 7112
  • [30] Variational principles for mechanistic quantitative structure-activity relationship (QSAR) studies: application on uracil derivatives' anti-HIV action
    Putz, Mihai V.
    Dudas, Nicoleta A.
    STRUCTURAL CHEMISTRY, 2013, 24 (06) : 1873 - 1893
12345