Quantitative structure activity reiationship (QSAR) studies on anti-HIV-1 and cytotoxic arylpyrrolylsulfones

被引：0
|
作者：
Srivastava, AK [1 ]
Khan, AA [1 ]
Shakil, M [1 ]
机构：
[1] Univ Allahabad, Dept Chem, Allahabad 211002, Uttar Pradesh, India
来源：
JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2001年 / 78卷 / 03期
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D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
QSAR studies of anti-HIV-1 and cytotoxic arylpyrrolylsulfones (1-51) have been discussed. The cytotoxicity of these compound is found to be dominantly controlled by electronic and hydrophobic factors whereas anti-HIV1 activity is controlled by steric factor. Significant correlations have been obtained between cytotoxicity and equalized electronegativity X-eq, partition coefficient log P, and anti-HIV-1 activity with molecular connectivity (1)x(b).
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页码：154 / 157
页数：4
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