Quantitative structure-activity relationship studies on some acyclouridine derivatives acting as anti-HIV-1 drugs

被引：15
|
作者：
Garg, R
Kurup, A
Gupta, SP
机构：
[1] BIRLA INST TECHNOL & SCI,DEPT CHEM,PILANI 333031,RAJASTHAN,INDIA
[2] BIRLA INST TECHNOL & SCI,DEPT PHARM,PILANI 333031,RAJASTHAN,INDIA
来源：
QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS | 1997年 / 16卷 / 01期
关键词：
quantitative structure-activity relationship; HIV-1; inhibitors; HEPT derivatives;
D O I：
10.1002/qsar.19970160104
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The anti-HIV-1 activity of some derivatives of 1-[2-hydroxyethoxy]-6-(phenylthio)thymine(HEPT) is analyzed in relation to their physicochemical and molecular properties. The activities of the compounds are found to be significantly correlated with hydrophobic constant 71 and the van der Waals volume V-w. The results are found to be useful in discussing the mechanism of drug-receptor interaction.
引用
收藏
页码：20 / 24
页数：5
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