Quantitative structure-activity relationship studies on some acyclouridine derivatives acting as anti-HIV-1 drugs

被引：15
|
作者：
Garg, R
Kurup, A
Gupta, SP
机构：
[1] BIRLA INST TECHNOL & SCI,DEPT CHEM,PILANI 333031,RAJASTHAN,INDIA
[2] BIRLA INST TECHNOL & SCI,DEPT PHARM,PILANI 333031,RAJASTHAN,INDIA
来源：
QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS | 1997年 / 16卷 / 01期
关键词：
quantitative structure-activity relationship; HIV-1; inhibitors; HEPT derivatives;
D O I：
10.1002/qsar.19970160104
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The anti-HIV-1 activity of some derivatives of 1-[2-hydroxyethoxy]-6-(phenylthio)thymine(HEPT) is analyzed in relation to their physicochemical and molecular properties. The activities of the compounds are found to be significantly correlated with hydrophobic constant 71 and the van der Waals volume V-w. The results are found to be useful in discussing the mechanism of drug-receptor interaction.
引用
收藏
页码：20 / 24
页数：5
相关论文
共 50 条
  • [31] Quantitative structure-activity relationship studies of 1,2,4-triazole derivatives
    Wei, Qing-Li
    Gao, Jun
    Zou, Jin
    Wan, Jun
    Zhang, Shu-Sheng
    ASIAN JOURNAL OF CHEMISTRY, 2007, 19 (02) : 1262 - 1268
  • [32] CYCLOSPORINES - IMMUNOSUPPRESSIVE DRUGS WITH ANTI-HIV-1 ACTIVITY
    THALI, M
    MOLECULAR MEDICINE TODAY, 1995, 1 (06): : 287 - 291
  • [33] Medicinal Chemistry of Anti-HIV-1 Latency Chemotherapeutics: Biotargets, Binding Modes and Structure-Activity Relationship Investigation
    Wang, Yan-Kai
    Wei, Long
    Hu, Wei
    Yu, Pei-Xia
    Li, Zhong
    Yu, Hai-Peng
    Li, Xun
    MOLECULES, 2023, 28 (01):
  • [34] Quantitative structure-activity relationship (QSAR) studies on non steroidal anti-inflammatory drugs (NSAIDs)
    Hadjipavlou-Litina, D
    CURRENT MEDICINAL CHEMISTRY, 2000, 7 (04) : 375 - 388
  • [35] Quantitative structure-activity relationship studies on 1-aryl-tetrahydroisoquinoline analogs as active anti-HIV agents
    Chen, Ke-xian
    Xie, Hai-ying
    Li, Zu-guang
    Gao, Jian-rong
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (20) : 5381 - 5386
  • [36] Anti-HIV-1 activity of carborane derivatives of porphyrins
    Debnath, AK
    Jiang, SB
    Strick, N
    Lin, K
    Kahl, SB
    Neurath, AR
    MEDICINAL CHEMISTRY RESEARCH, 1999, 9 (04) : 267 - 275
  • [37] Pyrazolone Derivatives: Synthesis, Anti-inflammatory, Analgesic, Quantitative Structure-Activity Relationship and in Vitro Studies
    Ragab, Fatma Abdel-Fattah
    Abdel-Gawad, Nagwa Mohamed
    Georgey, Hanan Hanna
    Said, Mona Fikry
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2013, 61 (08) : 834 - 845
  • [38] STRUCTURE-ACTIVITY RELATIONSHIP OF SOME PHENCYCLIDINE DERIVATIVES - INVIVO STUDIES IN MICE
    KALIR, A
    MAAYANI, S
    REHAVI, M
    ELKAVETS, R
    PRIBAR, I
    BUCHMAN, O
    SOKOLOVSKY, M
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1978, 13 (01) : 17 - 24
  • [39] Quantitative structure-activity relationship of some pesticides
    Praba, G. Om
    Velmurugan, D.
    INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS, 2007, 44 (06): : 470 - 476
  • [40] A quantitative structure-activity relationship study on some aromatic/heterocyclic sulfonamides and their charged derivatives acting as carbonic anhydrase inhibitors
    Gupta, SP
    Kumaran, S
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2005, 20 (03) : 251 - 259
12345