Quantitative structure activity reiationship (QSAR) studies on anti-HIV-1 and cytotoxic arylpyrrolylsulfones

被引：0
|
作者：
Srivastava, AK [1 ]
Khan, AA [1 ]
Shakil, M [1 ]
机构：
[1] Univ Allahabad, Dept Chem, Allahabad 211002, Uttar Pradesh, India
来源：
JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2001年 / 78卷 / 03期
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
QSAR studies of anti-HIV-1 and cytotoxic arylpyrrolylsulfones (1-51) have been discussed. The cytotoxicity of these compound is found to be dominantly controlled by electronic and hydrophobic factors whereas anti-HIV1 activity is controlled by steric factor. Significant correlations have been obtained between cytotoxicity and equalized electronegativity X-eq, partition coefficient log P, and anti-HIV-1 activity with molecular connectivity (1)x(b).
引用
收藏
页码：154 / 157
页数：4
相关论文
共 50 条
  • [31] INVITRO ANTI-HIV-1 ACTIVITY OF CHONDROITIN POLYSULFATE
    JURKIEWICZ, E
    PANSE, P
    JENTSCH, KD
    HARTMANN, H
    HUNSMANN, G
    AIDS, 1989, 3 (07) : 423 - 427
  • [32] CYCLOSPORINES - IMMUNOSUPPRESSIVE DRUGS WITH ANTI-HIV-1 ACTIVITY
    THALI, M
    MOLECULAR MEDICINE TODAY, 1995, 1 (06): : 287 - 291
  • [33] Anti-HIV-1 activity of carborane derivatives of porphyrins
    Debnath, AK
    Jiang, SB
    Strick, N
    Lin, K
    Kahl, SB
    Neurath, AR
    MEDICINAL CHEMISTRY RESEARCH, 1999, 9 (04) : 267 - 275
  • [34] Mechanism of thrombospondin-1 anti-HIV-1 activity
    Crombie, R
    AIDS PATIENT CARE AND STDS, 2000, 14 (04) : 211 - 214
  • [35] Preliminary crystallographic studies of an anti-HIV-1 protease antibody that inhibits enzyme activity
    Lescar, J
    Stouracova, R
    Riottot, MM
    Chitarra, V
    Brynda, J
    Fabry, M
    Horejsi, M
    Sedlacek, J
    Bentley, GA
    PROTEIN SCIENCE, 1996, 5 (05) : 966 - 968
  • [36] Variational principles for mechanistic quantitative structure–activity relationship (QSAR) studies: application on uracil derivatives’ anti-HIV action
    Mihai V. Putz
    Nicoleta A. Dudaş
    Structural Chemistry, 2013, 24 : 1873 - 1893
  • [37] ANTI-HIV-1 ACTIVITY, TOXICITY, AND STABILITY STUDIES OF REPRESENTATIVE STRUCTURAL FAMILIES OF POLYOXOMETALATES
    HILL, CL
    WEEKS, MS
    SCHINAZI, RF
    JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (10) : 2767 - 2772
  • [38] Understanding the structure-activity relationship of betulinic acid derivatives as anti-HIV-1 agents by using 3D-QSAR and docking
    Ping Lan
    Wan-Na Chen
    Zhi-Jian Huang
    Ping-Hua Sun
    Wei-Min Chen
    Journal of Molecular Modeling, 2011, 17 : 1643 - 1659
  • [39] Understanding the structure-activity relationship of betulinic acid derivatives as anti-HIV-1 agents by using 3D-QSAR and docking
    Lan, Ping
    Chen, Wan-Na
    Huang, Zhi-Jian
    Sun, Ping-Hua
    Chen, Wei-Min
    JOURNAL OF MOLECULAR MODELING, 2011, 17 (07) : 1643 - 1659
  • [40] SYNTHESIS OF A CYANOBACTERIAL SULFOLIPID - CONFIRMATION OF ITS STRUCTURE, STEREOCHEMISTRY, AND ANTI-HIV-1 ACTIVITY
    GORDON, DM
    DANISHEFSKY, SJ
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (02) : 659 - 663
12345