Cytogenetic analysis of 60Co γ-radiation-induced chromosome damage and simulations using the Geant4 Monte Carlo toolkit

被引：0
|
作者：
Fourie, H. [1 ]
Newman, R. T. [1 ]
Slabbert, J. P. [2 ]
Beukes, P. [2 ]
机构：
[1] Univ Stellenbosch, Dept Phys, ZA-7602 Stellenbosch, South Africa
[2] Natl Res Fdn, IThemba LABS, ZA-7129 Somerset West, South Africa
来源：
PROCEEDINGS OF SAIP2013: THE 58TH ANNUAL CONFERENCE OF THE SOUTH AFRICAN INSTITUTE OF PHYSICS | 2013年
关键词：
BLOOD-LYMPHOCYTES; MICRONUCLEUS; NEUTRONS; RAYS;
D O I：
暂无
中图分类号：
O59 [应用物理学];
学科分类号：
摘要：
The study involves the determination and quantization of radiation damage on a cellular level and the replication of this energy deposition using the Geant4 Monte Carlo toolkit, developed for particle transportation simulations at CERN. The detection of micronuclei in binucleated cells was used to analyse the effects of the radiation. Results from micronucleus assays of rat brain endothelial and Chinese hamster ovary cells that have been irradiated with gamma rays, produced by a Co-60 teletherapy unit at iThemba LABS, are presented. Linear-quadratic dose response curves were determined for both cell lines. The simulated results of the Co-60 setup, irradiation and other relevant features offered by the Geant4 toolkit are also discussed. Finally, prospective microdosimetric studies and simulations of damage caused by DNA-incorporated I-123 will be mentioned.
引用
收藏
页码：248 / 253
页数：6
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