Cytogenetic analysis of 60Co γ-radiation-induced chromosome damage and simulations using the Geant4 Monte Carlo toolkit

被引：0
|
作者：
Fourie, H. [1 ]
Newman, R. T. [1 ]
Slabbert, J. P. [2 ]
Beukes, P. [2 ]
机构：
[1] Univ Stellenbosch, Dept Phys, ZA-7602 Stellenbosch, South Africa
[2] Natl Res Fdn, IThemba LABS, ZA-7129 Somerset West, South Africa
来源：
PROCEEDINGS OF SAIP2013: THE 58TH ANNUAL CONFERENCE OF THE SOUTH AFRICAN INSTITUTE OF PHYSICS | 2013年
关键词：
BLOOD-LYMPHOCYTES; MICRONUCLEUS; NEUTRONS; RAYS;
D O I：
暂无
中图分类号：
O59 [应用物理学];
学科分类号：
摘要：
The study involves the determination and quantization of radiation damage on a cellular level and the replication of this energy deposition using the Geant4 Monte Carlo toolkit, developed for particle transportation simulations at CERN. The detection of micronuclei in binucleated cells was used to analyse the effects of the radiation. Results from micronucleus assays of rat brain endothelial and Chinese hamster ovary cells that have been irradiated with gamma rays, produced by a Co-60 teletherapy unit at iThemba LABS, are presented. Linear-quadratic dose response curves were determined for both cell lines. The simulated results of the Co-60 setup, irradiation and other relevant features offered by the Geant4 toolkit are also discussed. Finally, prospective microdosimetric studies and simulations of damage caused by DNA-incorporated I-123 will be mentioned.
引用
收藏
页码：248 / 253
页数：6
相关论文
共 50 条
  • [21] Gamma backscattering analysis of flaw types and orientation based on Monte Carlo GEANT4 simulations
    Wirawan, R.
    Angraini, L. M.
    Qomariyah, N.
    Waris, A.
    Djamal, M.
    APPLIED RADIATION AND ISOTOPES, 2020, 155
  • [22] On the ionizing radiation protection properties of different chromium-based alloys: A study with the Geant4 Monte Carlo toolkit
    Hamad, Morad Kh.
    ANNALS OF NUCLEAR ENERGY, 2025, 213
  • [23] Geant4 Monte Carlo Simulations of the belt proton radiation environment on board the international space Station/Columbus
    Ersmark, Tore
    Carlson, Per
    Daly, Earnorm
    Fuglesang, Christer
    Gudowska, Irena
    Lund-Jensen, Bengt
    Nierninen, Petteri
    Pearce, Mark
    Santin, Giovanni
    IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 2007, 54 (04) : 1444 - 1453
  • [24] External dose assessment of NORM added consumer products using Geant4 Monte Carlo simulations
    Hassan, Halmat J.
    Hashim, S.
    Abu Hanifah, N. Z. H.
    Sanusi, M. S. M.
    Fahmi, M. R.
    Tahar, R. M.
    Bradley, D. A.
    RADIATION PHYSICS AND CHEMISTRY, 2022, 200
  • [25] Optimization of an ultra-fast silicon detector for proton and carbon beams using GEANT4 Monte Carlo toolkit
    Mashayekhi, Mohsen
    Mowlavi, Ali Asghar
    Jia, Sayyed Bijan
    Ghayoumizadeh, Hossein
    REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY, 2020, 25 (01) : 109 - 112
  • [26] Using Geant4 Monte Carlo toolkit to evaluate a low power X-ray tube generator configuration
    Hoff, G.
    Streck, E. E.
    Lai, A.
    Fanti, V
    Golosio, B.
    Nascimento, C. D.
    Souza, E. G.
    APPLIED RADIATION AND ISOTOPES, 2021, 168
  • [27] Implementation of detector response function modeling for small animal SPECT using Geant4 Monte Carlo Simulation Toolkit
    El Bitar, Ziad
    Brasse, David
    Gullberg, Grant
    JOURNAL OF NUCLEAR MEDICINE, 2012, 53
  • [28] Radioactive gold nanoparticles for cancer treatmentSize and cluster dependent damage studied by Geant4 Monte-Carlo simulations
    Julan Mateo Zutta Villate
    Marc Benjamin Hahn
    The European Physical Journal D, 2019, 73
  • [29] Proton Therapy Range Verification Using Prompt Gamma Rays: A Simulation Study with the Geant4 Monte Carlo Toolkit
    Lau, A.
    Chen, Y.
    Ahmad, S.
    MEDICAL PHYSICS, 2013, 40 (06)
  • [30] Cancer risk estimation in Digital Breast Tomosynthesis using GEANT4 Monte Carlo simulations and voxel phantoms
    Ferreira, P.
    Baptista, M.
    Di Maria, S.
    Vaz, P.
    PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 2016, 32 (05): : 717 - 723
12345