Synthesis and cytostatic properties of some 6H-indolo[2,3-b][18]naphthyridine derivatives

被引：11
|
作者：
Mastalarz, H
Jasztold-Howorko, R
Rulko, F
Croisy, A
Carrez, D
机构：
[1] Univ Med Wroclaw, Dept Organ Chem Med, PL-50137 Wroclaw, Poland
[2] INSERM, Inst Curie, Biol Sect, U350, Orsay, France
来源：
ARCHIV DER PHARMAZIE | 2004年 / 337卷 / 08期
关键词：
6H-indolo[2,3-b][1,8]naphthyridines; synthesis; cytotoxicity;
D O I：
10.1002/ardp.200200696
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The new and efficient synthesis of the title heterocyclic ring system is described starting from suitable 2-chloro-1,8-naphthyridines. The synthesized 6H-indolo[2,3-b][1,8]naphthyridine derivatives were tested in vitro on 55 tumor cell lines for their anticancer properties. The presence of the acetylamino moiety at position 3 in the main ring system proved to be crucial for the cytostatic activity of this class of compounds.
引用
收藏
页码：434 / 439
页数：6
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