Design, synthesis and antimicrobial studies of novel imine derivatives of 2-(6H-indolo[2,3-b] quinoxalin-6-yl)-1-phenylethan-1-ones

被引：0
|
作者：
Melnichenko, Vasily E. [1 ]
Kudryavtseva, Tatyana N. [1 ]
Lamanov, Alexey Y. [1 ]
Kudryavcev, Timofey A. [1 ]
Klimova, Lyudmila G. [2 ]
机构：
[1] Kursk State Univ, Dept Chem, Kursk 305000, Russia
[2] Kursk State Med Univ, Dept Microbiol, Kursk 305041, Russia
来源：
CHEMICAL DATA COLLECTIONS | 2022年 / 41卷
关键词：
6H-indolo[2; 3-b]quinoxaline; Hydroxylamine; Thiosemicarbazide; Antimicrobial activity; BIOLOGICAL EVALUATION; CYTOTOXIC EVALUATION; DNA;
D O I：
10.1016/j.cdc.2022.100929
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of new imine derivatives 2-(6H-indolo[2,3-b]quinoxalin-6-yl)-1-phenylethan-1-ones was synthesized by various methods in good yields and characterized through IR, NMR and Mass spectral analysis. Some compounds were screened for their in vitro antimicrobial activity against five bacterial and one fungal pathogens. Compound 4a showed greater efficiency than Rivanol against gram-negative bacteria Escherichia coli and Proteus Vulgaris and a fungal strain of Candida albicans.
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页数：6
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