Synthesis and cytostatic properties of some 6H-indolo[2,3-b][18]naphthyridine derivatives

被引：11

作者：

Mastalarz, H

Jasztold-Howorko, R

Rulko, F

Croisy, A

Carrez, D

机构：

[1] Univ Med Wroclaw, Dept Organ Chem Med, PL-50137 Wroclaw, Poland

[2] INSERM, Inst Curie, Biol Sect, U350, Orsay, France

来源：

ARCHIV DER PHARMAZIE | 2004年 / 337卷 / 08期

关键词：

6H-indolo[2,3-b][1,8]naphthyridines; synthesis; cytotoxicity;

D O I：

10.1002/ardp.200200696

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The new and efficient synthesis of the title heterocyclic ring system is described starting from suitable 2-chloro-1,8-naphthyridines. The synthesized 6H-indolo[2,3-b][1,8]naphthyridine derivatives were tested in vitro on 55 tumor cell lines for their anticancer properties. The presence of the acetylamino moiety at position 3 in the main ring system proved to be crucial for the cytostatic activity of this class of compounds.

引用

页码：434 / 439

页数：6

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