Combinatorial self-assembly of cyclophilin hCyp-18 ligands through rhenium coordination

被引：11

作者：

Clavaud, Cecile ^{[1
]}

Heckenroth, Marion ^{[1
]}

Stricane, Charlotte ^{[1
]}

Lelait, Marie-Anne ^{[1
]}

Menez, Andre ^{[1
]}

Dugave, Christophe ^{[1
]}

机构：

[1] CEA Saclay, Dept Ingn & Etud Prot, F-91191 Gif Sur Yvette, France

来源：

CHEMBIOCHEM | 2006年 / 7卷 / 09期

关键词：

combinatorial chemistry; isomerases; peptidomimetics; rhenium; self-assembly;

D O I：

10.1002/cbic.200600204

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Re ligands. The combinatorial assembly of independent modules A and B through oxorhenium(V) coordination was investigated, and the oxorhenium complexes A·ReVO·B were evaluated as novel ligands of cyclophilin hCyp-18. Two rhenium complexes that bind to hCyp-18 with an affinity more than one order of magnitude higher than that of the corresponding modules were selected from two libraries (288 rhenium complexes). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1352 / 1355

页数：4

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