Combinatorial self-assembly of cyclophilin hCyp-18 ligands through rhenium coordination

被引：11
|
作者：
Clavaud, Cecile [1 ]
Heckenroth, Marion [1 ]
Stricane, Charlotte [1 ]
Lelait, Marie-Anne [1 ]
Menez, Andre [1 ]
Dugave, Christophe [1 ]
机构：
[1] CEA Saclay, Dept Ingn & Etud Prot, F-91191 Gif Sur Yvette, France
来源：
CHEMBIOCHEM | 2006年 / 7卷 / 09期
关键词：
combinatorial chemistry; isomerases; peptidomimetics; rhenium; self-assembly;
D O I：
10.1002/cbic.200600204
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Re ligands. The combinatorial assembly of independent modules A and B through oxorhenium(V) coordination was investigated, and the oxorhenium complexes A·ReVO·B were evaluated as novel ligands of cyclophilin hCyp-18. Two rhenium complexes that bind to hCyp-18 with an affinity more than one order of magnitude higher than that of the corresponding modules were selected from two libraries (288 rhenium complexes). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：1352 / 1355
页数：4
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