α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria

被引：48

作者：

Zee, Tiffany ^{[1
,2
]}

Bose, Neelanjan ^{[1
,2
]}

Zee, Jarcy ^{[3
]}

Beck, Jennifer N. ^{[1
,2
]}

Yang, See ^{[2
]}

Parihar, Jaspreet ^{[4
]}

Yang, Min ^{[5
,6
]}

Damodar, Sruthi ^{[2
]}

Hall, David ^{[2
]}

O'Leary, Monique N. ^{[2
]}

Ramanathan, Arvind ^{[2
]}

Gerona, Roy R. ^{[7
]}

Killilea, David W. ^{[1
,8
]}

Chi, Thomas ^{[1
]}

Tischfield, Jay ^{[5
,6
]}

Sahota, Amrik ^{[5
,6
]}

Kahn, Arnold ^{[2
]}

Stoller, Marshall L. ^{[1
]}

Kapahi, Pankaj ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Dept Urol, San Francisco, CA 94117 USA

[2] Buck Inst Res Aging, Novato, CA 94945 USA

[3] Arbor Res Collaborat Hlth, Ann Arbor, MI USA

[4] Rutgers State Univ, Robert Wood Johnson Med Sch, Div Urol, New Brunswick, NJ USA

[5] Rutgers State Univ, Dept Genet, Piscataway, NJ USA

[6] Rutgers State Univ, Human Genet Inst New Jersey, Piscataway, NJ USA

[7] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA 94143 USA

[8] Childrens Hosp, Oakland Res Inst, Nutr & Metab Ctr, 747 52nd St, Oakland, CA 94609 USA

来源：

NATURE MEDICINE | 2017年 / 23卷 / 03期

关键词：

KIDNEY-STONES; GLUTATHIONE; DISEASE;

D O I：

10.1038/nm.4280

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and are often poorly tolerated. We report that the nutritional supplement alpha-lipoic acid inhibits cystine stone formation in the Slc3a1(-/-) mouse model of cystinuria by increasing the solubility of urinary cystine. These findings identify a novel therapeutic strategy for the clinical treatment of cystinuria.

引用

页码：288 / 290

页数：3

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