α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria

被引：48
|
作者：
Zee, Tiffany [1 ,2 ]
Bose, Neelanjan [1 ,2 ]
Zee, Jarcy [3 ]
Beck, Jennifer N. [1 ,2 ]
Yang, See [2 ]
Parihar, Jaspreet [4 ]
Yang, Min [5 ,6 ]
Damodar, Sruthi [2 ]
Hall, David [2 ]
O'Leary, Monique N. [2 ]
Ramanathan, Arvind [2 ]
Gerona, Roy R. [7 ]
Killilea, David W. [1 ,8 ]
Chi, Thomas [1 ]
Tischfield, Jay [5 ,6 ]
Sahota, Amrik [5 ,6 ]
Kahn, Arnold [2 ]
Stoller, Marshall L. [1 ]
Kapahi, Pankaj [1 ,2 ]
机构：
[1] Univ Calif San Francisco, Dept Urol, San Francisco, CA 94117 USA
[2] Buck Inst Res Aging, Novato, CA 94945 USA
[3] Arbor Res Collaborat Hlth, Ann Arbor, MI USA
[4] Rutgers State Univ, Robert Wood Johnson Med Sch, Div Urol, New Brunswick, NJ USA
[5] Rutgers State Univ, Dept Genet, Piscataway, NJ USA
[6] Rutgers State Univ, Human Genet Inst New Jersey, Piscataway, NJ USA
[7] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA 94143 USA
[8] Childrens Hosp, Oakland Res Inst, Nutr & Metab Ctr, 747 52nd St, Oakland, CA 94609 USA
来源：
NATURE MEDICINE | 2017年 / 23卷 / 03期
关键词：
KIDNEY-STONES; GLUTATHIONE; DISEASE;
D O I：
10.1038/nm.4280
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and are often poorly tolerated. We report that the nutritional supplement alpha-lipoic acid inhibits cystine stone formation in the Slc3a1(-/-) mouse model of cystinuria by increasing the solubility of urinary cystine. These findings identify a novel therapeutic strategy for the clinical treatment of cystinuria.
引用
收藏
页码：288 / 290
页数：3
相关论文
共 50 条
  • [31] Effect of treatment on measurements of cystine excretion (CysEx) and saturation (CysSS) in cystinuria.
    Goldfarb, DS
    Coe, FL
    Asplin, JR
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2003, 14 : 702A - 702A
  • [32] TREATMENT AND RESULTS OF CYSTINURIA AND CYSTINE URINARY CALCULI BY ADMINISTRATION OF ALPHA-MERCAPTOPROPIONYLGLYCINE
    GIANNAKOPOULOS, X
    KALFAKAKOU, V
    TSOUMANIS, P
    KARKABOUNAS, S
    GIANNAKIS, D
    CHAMBILOMATIS, P
    EVANGELOU, A
    KALLISTRATOS, G
    JOURNAL D UROLOGIE, 1994, 100 (03) : 129 - 134
  • [33] S-Methyl-L-Ergothioneine to L-Ergothioneine Ratio in Urine Is a Marker of Cystine Lithiasis in a Cystinuria Mouse Model
    Lopez de Heredia, Miguel
    Munoz, Lourdes
    Carru, Ciriaco
    Sotgia, Salvatore
    Zinellu, Angelo
    Serra, Carmen
    Llebaria, Amadeu
    Kato, Yukio
    Nunes, Virginia
    ANTIOXIDANTS, 2021, 10 (09)
  • [34] ALPHA-LIPOIC ACID PREVENTS DIABETIC CATARACTOGENESIS
    PACKER, L
    DIABETOLOGIA, 1994, 37 : A211 - A211
  • [35] Lipoic Acid Prevents Renal Dysfunction in Experimental Diabetes
    Fonteles, Manasses Claudino
    Silva, Ariana Gomes
    Sousa Fonseca, Maria Julia
    Santos, Claudia Ferreira
    Lima Lopes, Davi Elisiario
    Matos Silva, Matheus Carlos
    Falcao Nascimento, Nilberto Robson
    FASEB JOURNAL, 2019, 33
  • [36] Lipoic acid prevents insulin resistance and adipocyte inflammation
    Sun, Qinghua
    Chang, Theodore
    Kampfrath, Thomas
    Lumeng, Carey N.
    Yue, Peibin
    Vedamoorthy, Srikanth
    Desikan, Raju
    Parthasarathy, Sampath
    Khan, Bobby
    Rajagopalan, Sanjay
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 51 (10) : A294 - A294
  • [37] TREATMENT OF CYSTINURIA WITH ASCORBIC-ACID
    不详
    AKTUELLE UROLOGIE, 1982, 13 (02) : 81 - 81
  • [38] MEDICAL THERAPY OF CYSTINURIA: EVALUATION IN MOUSE MODEL
    Wendt-Nordahl, Gunnar
    Meister, Lioba
    Honeck, Patrick
    Michel, Maurice Stephan
    Knoll, Thomas
    JOURNAL OF UROLOGY, 2010, 183 (04): : E509 - E509
  • [39] Effect of the Antioxidant Lipoic Acid in Aortic Phenotype in a Marfan Syndrome Mouse Model
    Guido, Maria C.
    Debbas, Victor
    Salemi, Vera M.
    Tavares, Elaine R.
    Meirelles, Thayna
    Araujo, Thais L. S.
    Nolasco, Patricia
    Ferreira-Filho, Julio C. A.
    Takimura, Celso K.
    Pereira, Lygia V.
    Laurindo, Francisco R.
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018, 2018
  • [40] DISSOLUTION OF CYSTINE STONES DURING D-PENICILLAMINE TREATMENT OF A PREGNANT PATIENT WITH CYSTINURIA
    CRAWHALL, JC
    SCOWEN, EF
    THOMPSON, CJ
    WATTS, RWE
    BMJ-BRITISH MEDICAL JOURNAL, 1967, 2 (5546): : 216 - +
12345