α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria

被引：48
|
作者：
Zee, Tiffany [1 ,2 ]
Bose, Neelanjan [1 ,2 ]
Zee, Jarcy [3 ]
Beck, Jennifer N. [1 ,2 ]
Yang, See [2 ]
Parihar, Jaspreet [4 ]
Yang, Min [5 ,6 ]
Damodar, Sruthi [2 ]
Hall, David [2 ]
O'Leary, Monique N. [2 ]
Ramanathan, Arvind [2 ]
Gerona, Roy R. [7 ]
Killilea, David W. [1 ,8 ]
Chi, Thomas [1 ]
Tischfield, Jay [5 ,6 ]
Sahota, Amrik [5 ,6 ]
Kahn, Arnold [2 ]
Stoller, Marshall L. [1 ]
Kapahi, Pankaj [1 ,2 ]
机构：
[1] Univ Calif San Francisco, Dept Urol, San Francisco, CA 94117 USA
[2] Buck Inst Res Aging, Novato, CA 94945 USA
[3] Arbor Res Collaborat Hlth, Ann Arbor, MI USA
[4] Rutgers State Univ, Robert Wood Johnson Med Sch, Div Urol, New Brunswick, NJ USA
[5] Rutgers State Univ, Dept Genet, Piscataway, NJ USA
[6] Rutgers State Univ, Human Genet Inst New Jersey, Piscataway, NJ USA
[7] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA 94143 USA
[8] Childrens Hosp, Oakland Res Inst, Nutr & Metab Ctr, 747 52nd St, Oakland, CA 94609 USA
来源：
NATURE MEDICINE | 2017年 / 23卷 / 03期
关键词：
KIDNEY-STONES; GLUTATHIONE; DISEASE;
D O I：
10.1038/nm.4280
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and are often poorly tolerated. We report that the nutritional supplement alpha-lipoic acid inhibits cystine stone formation in the Slc3a1(-/-) mouse model of cystinuria by increasing the solubility of urinary cystine. These findings identify a novel therapeutic strategy for the clinical treatment of cystinuria.
引用
收藏
页码：288 / 290
页数：3
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