Cascade Synthesis of 3-Alkylidene Dihydrobenzofuran Derivatives via Rhodium(III)-Catalyzed Redox-Neutral C-H Functionalization/Cyclization

被引：67

作者：

Zhou, Zhi ^{[1
]}

Liu, Guixia ^{[1
]}

Chen, Yan ^{[1
]}

Lu, Xiyan ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 23期

基金：

中国国家自然科学基金;

关键词：

N-PHENOXYACETAMIDES; INDOLE SYNTHESIS; ACTIVATION; BOND; ALKYNES; MILD; ANNULATION; ACCESS; ARYLNITRONES; CONSTRUCTION;

D O I：

10.1021/acs.orglett.5b03060

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient rhodium(III)-catalyzed coupling reaction of N-phenoxyacetamides with propargyl carbonates to yield 3-alkylidene dihydrobenzofuran derivatives via C-H functionalization/cascade cyclization has been developed. This transformation represents a redox-neutral process and features the formation of three new bonds under mild conditions.

引用

页码：5874 / 5877

页数：4

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