Highly diastereoselective synthesis of polycyclic amines via redox neutral C-H functionalization

被引：23
|
作者：
Kumar, Chottanahalli S. Pavan [1 ]
Harsha, Kachigere B. [1 ]
Sandhya, Nagarakere C. [1 ]
Ramesha, Ajjalli B. [1 ]
Mantelingu, Kempegowda [1 ]
Rangappa, Kanchugarakoppal S. [1 ]
机构：
[1] Univ Mysore, DOS Chem, Mysuru 570006, India
来源：
NEW JOURNAL OF CHEMISTRY | 2015年 / 39卷 / 11期
关键词：
1,3-DIPOLAR CYCLOADDITION; BOND FUNCTIONALIZATION; AZOMETHINE YLIDES; SECONDARY-AMINES; HYDRIDE TRANSFER; TANDEM APPROACH; METAL; ACTIVATION; TETRAHYDROISOQUINOLINES; CYCLOCONDENSATION;
D O I：
10.1039/c5nj01706h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Synthesis of polycyclic amines was achieved by benzoic acid catalysed reaction of 1-aryl THIQs and 1-aryl trypolines with o-allyl salicylaldehydes through the in situ generated azomethine ylide intermediates that undergo intramolecular [3+2]-cycloadditions with four new stereogenic centers in excellent diastereoselectivities under simple and mild conditions.
引用
收藏
页码：8397 / 8404
页数：8
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