Cascade Synthesis of 3-Alkylidene Dihydrobenzofuran Derivatives via Rhodium(III)-Catalyzed Redox-Neutral C-H Functionalization/Cyclization

被引：67
|
作者：
Zhou, Zhi [1 ]
Liu, Guixia [1 ]
Chen, Yan [1 ]
Lu, Xiyan [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2015年 / 17卷 / 23期
基金：
中国国家自然科学基金;
关键词：
N-PHENOXYACETAMIDES; INDOLE SYNTHESIS; ACTIVATION; BOND; ALKYNES; MILD; ANNULATION; ACCESS; ARYLNITRONES; CONSTRUCTION;
D O I：
10.1021/acs.orglett.5b03060
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient rhodium(III)-catalyzed coupling reaction of N-phenoxyacetamides with propargyl carbonates to yield 3-alkylidene dihydrobenzofuran derivatives via C-H functionalization/cascade cyclization has been developed. This transformation represents a redox-neutral process and features the formation of three new bonds under mild conditions.
引用
收藏
页码：5874 / 5877
页数：4
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