Redox-Neutral Couplings between Amides and Alkynes via Cobalt(III)-Catalyzed C-H Activation

被引：132
|
作者：
Kong, Lingheng [1 ]
Yu, Songjie [1 ]
Zhou, Xukai [1 ]
Li, Xingwei [1 ]
机构：
[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
来源：
ORGANIC LETTERS | 2016年 / 18卷 / 03期
关键词：
RUTHENIUM-CATALYZED CYCLIZATION; N-CARBAMOYL INDOLINES; REGIOSELECTIVE SYNTHESIS; INTERNAL ALKYNES; BOND FORMATION; ACCESS; ANNULATION; AMIDATION; ARYL; FUNCTIONALIZATION;
D O I：
10.1021/acs.orglett.5b03629
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
C-H activation assisted by a bifunctional directing group has allowed the construction of heterocycles. This is ideally catalyzed by earth-abundant and eco-friendly transition metals. We report Co(III)-catalyzed redox-neutral coupling between arenes and alkynes using an NH amide as an electrophilic directing group. The redox-neutral C-H activation/coupling afforded quinolines with water as the sole byproduct.
引用
收藏
页码：588 / 591
页数：4
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