Rhodium(III)-Catalyzed Redox-Neutral C-H Annulation of Arylnitrones and Alkynes for the Synthesis of Indole Derivatives

被引：51
|
作者：
Zhou, Zhi [1 ]
Liu, Guixia [1 ]
Chen, Yan [1 ]
Lu, Xiyan [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2015年 / 357卷 / 13期
基金：
中国国家自然科学基金;
关键词：
alkynes; annulation; C-H activation; nitrones; oxidizing directing group; rhodium; QUINOLINE N-OXIDES; EFFICIENT SYNTHESIS; BOND ACTIVATION; OXIDATIVE CYCLIZATION; FUNCTIONALIZATION; PHENOXYACETAMIDES; NITRONES; ISOQUINOLINES; ALKENYLATION; OLEFINATION;
D O I：
10.1002/adsc.201500580
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
By using a nitrone as the oxidizing directing group, a mild, practical and efficient rhodium(III)-catalyzed C-H functionalization for the synthesis of indole derivatives has been developed. This reaction obviates the need for an external oxidant and shows good functional group tolerance. The employment of a sterically hindered Mes group on the carbon center of the nitrone is crucial to produce indoles in high yield.
引用
收藏
页码：2944 / 2950
页数：7
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