Rh(III)-Catalyzed, Redox-Neutral, C-H Multifluoroalkenylation of Benzamides

被引：0

作者：

Lin, Wei ^{[1
]}

Qu, Yifei ^{[1
]}

Zhu, Huixuan ^{[1
]}

Xie, Mei ^{[1
]}

Hu, Jinhui ^{[1
]}

Xiong, Zhuang ^{[1
]}

Chen, Wen-Hua ^{[1
]}

Xu, Jun ^{[2
]}

Wu, Jia-Qiang ^{[1
]}

机构：

[1] Wuyi Univ, Sch Pharm & Food Engn, Jiangmen 529020, Peoples R China

[2] Sun Yat sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2024年 / 56卷 / 19期

关键词：

C-H activation; rhodium; multifluoroalkenylation; benzamide; redox-neutral; ALPHA-FLUOROALKENYLATION; ASYMMETRIC FLUORINATION; PERFLUOROALKYLATION; TRIFLUOROMETHYLATION; FUNCTIONALIZATION; ACCESS;

D O I：

10.1055/a-2343-0676

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Fluorinated molecules are widely used in pharmaceutical and agrochemical industries. Multifluoroalkyl-containing compounds have attracted increasing attention for their unique ability to alter the activity of drugs and bioactive molecules. Herein, we report an efficient Rh(III)-catalyzed, redox-neutral, C-H multifluoroalkenylation of benzamides with multifluoroalkenes, which provides a versatile protocol for accessing a wide range of multifluoroalkenylated arenes.

引用

页码：3045 / 3053

页数：9

共 50 条

[1] Rh(iii)-catalyzed redox-neutral C-H alkenylation of benzamides with gem-difluorohomoallylic silyl ethers via β-H elimination
Cui, Xueli
Qu, Jing
Yi, Jianfeng
Sun, Weiqiang
Hu, Jinhui
Guo, Suqin
Jin, Jing-Wei
Chen, Wen-Hua
Wong, Wing-Leung
Wu, Jia-Qiang
[J]. CHEMICAL COMMUNICATIONS, 2023, 59 (25) : 3747 - 3750
[2] Rh(III)-Catalyzed intramolecular redox-neutral cyclization of alkenes via C-H activation
Shi, Zhuangzhi
Boultadakis-Arapinis, Melissa
Koester, Dennis C.
Glorius, Frank
[J]. CHEMICAL COMMUNICATIONS, 2014, 50 (20) : 2650 - 2652
[3] Rhodium(III)-Catalyzed Redox-Neutral Coupling of α-Trifluoromethylacrylic Acid with Benzamides through Directed C-H Bond Cleavage
Yoshimoto, Risa
Usuki, Yoshinosuke
Satoh, Tetsuya
[J]. CHEMISTRY-AN ASIAN JOURNAL, 2020, 15 (06) : 802 - 806
[4] Rhodium(III)-Catalyzed Redox-Neutral C-H Arylation via Rearomatization
Zhang, Xueyun
Wang, Fen
Qi, Zisong
Yu, Songjie
Li, Xingwei
[J]. ORGANIC LETTERS, 2014, 16 (06) : 1586 - 1589
[5] Rh(III)-Catalyzed Redox-Neutral Unsymmetrical C-H Alkylation and Amidation Reactions of &ITN&IT-Phenoxyacetamides
Wu, Yunxiang
Chen, Zhaoqiang
Yang, Yaxi
Zhu, Weiliang
Zhou, Bing
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 140 (01) : 42 - 45
[6] Rh(III)-Catalyzed Redox-Neutral Cascade Annulation of Benzamides withp-Quinone Methides
Kanchupalli, Vinaykumar
Shukla, Rahul K.
Singh, Anurag
Volla, Chandra M. R.
[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2020, 2020 (29) : 4494 - 4498
[7] Rh(III)-Catalyzed Redox-Neutral Annulation of Primary Benzamides with Diazo Compounds: Approach to Isoquinolinones
Wu, Youzhi
Sun, Peng
Zhang, Kaifan
Yang, Tie
Yao, Hequan
Lin, Aijun
[J]. JOURNAL OF ORGANIC CHEMISTRY, 2016, 81 (05): : 2166 - 2173
[8] Mechanistic Understanding of Rh(III)-Catalyzed Redox-Neutral C-H Activation/Annulation Reactions of N-Phenoxyacetamides and Methyleneoxetanones
Xu, Man
Xia, Yuanzhi
[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 41 (08) : 3272 - 3278
[9] A Rh(III)-catalyzed redox-neutral C-H alkylation reaction with allylic alcohols by using a traceless oxidizing directing group
Wang, Yubo
Chen, Yu
Yang, Yaxi
Zhou, Bing
[J]. ORGANIC CHEMISTRY FRONTIERS, 2018, 5 (11): : 1844 - 1847
[10] Rh(III)-catalyzed C-H activation of benzamides: Coupling with quinones
Qi, Zisong
Li, Xingwei
[J]. CHINESE JOURNAL OF CATALYSIS, 2015, 36 (01) : 48 - 56

← 1 2 3 4 5 →