Cross-coupling of alkyl halides with aryl Grignard reagents catalyzed by a low-valent iron complex

被引：325
|
作者：
Martin, R [1 ]
Fürstner, A [1 ]
机构：
[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 30期
关键词：
alkyl halides; cross-coupling; Grignard reagents; iron;
D O I：
10.1002/anie.200460504
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A striking reversal of the usual reactivity pattern of aryl Grignard reagents is observed for reactions in the presence of catalytic amounts of the "bare" ferrate complex [Li(tmeda)]2[Fe(C2H 4)4] (1). Highly reduced iron-magnesium clusters may play a decisive role in the exceptionally facile and chemoselective cross-coupling reaction with alkyl halides (see scheme).
引用
收藏
页码：3955 / 3957
页数：3
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