Cross-Coupling of Nonactivated Primary and Secondary Alkyl Halides with Aryl Grignard Reagents Catalyzed by Chiral Iron Pincer Complexes

被引：16

作者：

Bauer, Gerald ^{[1
]}

Cheung, Chi Wai ^{[1
]}

Hu, Xile ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, Lab Inorgan Synth & Catalysis, ISIC LSCI, CH-1015 Lausanne, Switzerland

来源：

SYNTHESIS-STUTTGART | 2015年 / 47卷 / 12期

基金：

欧洲研究理事会;

关键词：

Kumada coupling; iron pincer complex; alkyl halide; aryl Grignard reagent; enantioselectivity; FRIEDEL-CRAFTS REACTION; BEARING BETA-HYDROGENS; PHOSPHINE;

D O I：

10.1055/s-0034-1380136

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Iron(III) bisoxazolinylphenylamido (bopa) pincer complexes are efficient precatalysts for the cross-coupling of nonactivated primary and secondary alkyl halides with phenyl Grignard reagents. The reactions proceed at room temperature in moderate to excellent yields. A variety of functional groups can be tolerated. The enantioselectivity of the coupling of secondary alkyl halides is low.

引用

页码：1726 / 1732

页数：7

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