Copper-Catalyzed Cross-Coupling of Alkyl and Aryl Grignard Reagents with Alkynyl Halides

被引：92
|
作者：
Cahiez, Gerard [1 ]
Gager, Olivier [1 ]
Buendia, Julien [1 ]
机构：
[1] Univ Paris 13, Dept Chem FRE 3043, CNRS, F-93017 Bobigny, France
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 07期
关键词：
alkynes; copper; cross-coupling; Grignard reagents; VINYL ORGANOCOPPER COMPOUNDS; STEREOSPECIFIC SYNTHESIS; DERIVATIVES; BROMIDES; ACIDS; CARBONATION; 1-ALKYNES; IODIDES;
D O I：
10.1002/anie.200905816
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Good old copperl A new general procedure to couple aliphatic and aromatic Grignard reagents with alkynyl halides under copper catalysis is described (see scheme; NMP=N-methylpyrrolidinone). The reaction is chemoselective and allows preparation of a vast array of simple and functionalized internal alkynes in high yields. © 2010 Wiley-VCH Verlag GmbH &. Co. KCaA.
引用
收藏
页码：1278 / 1281
页数：4
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