Emerging Biological Principles of Metastasis

被引：2207
|
作者：
Lambert, Arthur W. [1 ]
Pattabiraman, Diwakar R. [1 ]
Weinberg, Robert A. [1 ,2 ,3 ]
机构：
[1] Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA
[2] MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02142 USA
[3] MIT, Ludwig Ctr Mol Oncol, 77 Massachusetts Ave, Cambridge, MA 02142 USA
来源：
CELL | 2017年 / 168卷 / 04期
基金：
英国医学研究理事会;
关键词：
EPITHELIAL-MESENCHYMAL TRANSITION; CIRCULATING TUMOR-CELLS; BREAST-CANCER CELLS; STEM-LIKE CELLS; BONE-MARROW; LUNG ADENOCARCINOMA; T-CELLS; COLLECTIVE INVASION; DISTANT METASTASIS; BRAIN METASTASIS;
D O I：
10.1016/j.cell.2016.11.037
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Metastases account for the great majority of cancer-associated deaths, yet this complex process remains the least understood aspect of cancer biology. As the body of research concerning metastasis continues to grow at a rapid rate, the biological programs that underlie the dissemination and metastatic outgrowth of cancer cells are beginning to come into view. In this review we summarize the cellular and molecular mechanisms involved in metastasis, with a focus on carcinomas where the most is known, and we highlight the general principles of metastasis that have begun to emerge.
引用
收藏
页码：670 / 691
页数：22
相关论文
共 50 条
  • [41] Emerging Roles of Lipophagy in Cancer Metastasis
    Yin, Haimeng
    Shan, Ying
    Xia, Tian
    Ji, Yan
    Yuan, Ling
    You, Yiwen
    You, Bo
    CANCERS, 2022, 14 (18)
  • [42] Emerging and Established Models of Bone Metastasis
    Jinnah, Alexander H.
    Zacks, Benjamin C.
    Gwam, Chukwuweike U.
    Kerr, Bethany A.
    CANCERS, 2018, 10 (06)
  • [43] Epilepsy in brain metastasis: an emerging entity
    Ruda, Roberta
    Mo, Francesca
    Pellerino, Alessia
    CURRENT TREATMENT OPTIONS IN NEUROLOGY, 2020, 22 (02)
  • [44] Principles of Management of Extremity Skeletal Metastasis
    Gupta, Srinath
    Gulia, Ashish
    Kurisunkal, Vineet
    Parikh, Mishil
    Gupta, Sanjay
    INDIAN JOURNAL OF PALLIATIVE CARE, 2019, 25 (04) : 580 - 586
  • [45] Molecular principles of tissue invasion and metastasis
    Suresh, Dhanisha Sulekha
    Guruvayoorappan, Chandrasekharan
    AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2023, 324 (05): : C971 - C991
  • [46] Emerging principles in functional representations of touch
    Tame, Luigi
    Longo, Matthew R.
    NATURE REVIEWS PSYCHOLOGY, 2023, 2 (08): : 459 - 471
  • [47] Emerging principles in functional representations of touch
    Luigi Tamè
    Matthew R. Longo
    Nature Reviews Psychology, 2023, 2 : 459 - 471
  • [48] PRINCIPLES AND OTHER EMERGING PARADIGMS IN BIOETHICS
    BEAUCHAMP, TL
    INDIANA LAW JOURNAL, 1994, 69 (04) : 955 - 971
  • [49] Emerging principles of international environmental law
    Di Leva, Charles
    AMERICAN JOURNAL OF INTERNATIONAL LAW, 2007, 101 (04) : 933 - 938
  • [50] The Emerging Principles of Fourth Amendment Privacy
    Tokson, Matthew
    GEORGE WASHINGTON LAW REVIEW, 2020, 88 (01) : 1 - 75
12345