Emerging Biological Principles of Metastasis

被引：2207
|
作者：
Lambert, Arthur W. [1 ]
Pattabiraman, Diwakar R. [1 ]
Weinberg, Robert A. [1 ,2 ,3 ]
机构：
[1] Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA
[2] MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02142 USA
[3] MIT, Ludwig Ctr Mol Oncol, 77 Massachusetts Ave, Cambridge, MA 02142 USA
来源：
CELL | 2017年 / 168卷 / 04期
基金：
英国医学研究理事会;
关键词：
EPITHELIAL-MESENCHYMAL TRANSITION; CIRCULATING TUMOR-CELLS; BREAST-CANCER CELLS; STEM-LIKE CELLS; BONE-MARROW; LUNG ADENOCARCINOMA; T-CELLS; COLLECTIVE INVASION; DISTANT METASTASIS; BRAIN METASTASIS;
D O I：
10.1016/j.cell.2016.11.037
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Metastases account for the great majority of cancer-associated deaths, yet this complex process remains the least understood aspect of cancer biology. As the body of research concerning metastasis continues to grow at a rapid rate, the biological programs that underlie the dissemination and metastatic outgrowth of cancer cells are beginning to come into view. In this review we summarize the cellular and molecular mechanisms involved in metastasis, with a focus on carcinomas where the most is known, and we highlight the general principles of metastasis that have begun to emerge.
引用
收藏
页码：670 / 691
页数：22
相关论文
共 50 条
  • [31] Principles of biological Psychology
    Hermann, I.
    IMAGO, 1925, 11 (1-2): : 195 - 196
  • [32] PRINCIPLES OF BIOLOGICAL COMPARISON
    BOCK, WJ
    ACTA MORPHOLOGICA NEERLANDO-SCANDINAVICA, 1989, 27 (1-2) : 17 - 32
  • [33] Principles of Biological Psychology
    Wilken, Ernst
    ARCHIV FUR DIE GESAMTE PSYCHOLOGIE, 1914, 32 (1-2): : A5 - A11
  • [34] Current and emerging concepts in tumour metastasis
    Coghlin, Caroline
    Murray, Graeme I.
    JOURNAL OF PATHOLOGY, 2010, 222 (01): : 1 - 15
  • [35] Emerging Studies of Melanoma Brain Metastasis
    Caulfield, Jasmine, I
    Kluger, Harriet M.
    CURRENT ONCOLOGY REPORTS, 2022, 24 (05) : 585 - 594
  • [36] AN EMERGING INSIGHT INTO AN OLD PROBLEM - METASTASIS
    PACKARD, B
    TRENDS IN BIOCHEMICAL SCIENCES, 1986, 11 (12) : 490 - 491
  • [37] Emerging Studies of Melanoma Brain Metastasis
    Jasmine I. Caulfield
    Harriet M. Kluger
    Current Oncology Reports, 2022, 24 : 585 - 594
  • [38] Emerging drugs for the treatment of bone metastasis
    Pantano, Francesco
    Iuliani, Michele
    Zoccoli, Alice
    Fioramonti, Marco
    De Lisi, Delia
    Fioroni, Iacopo
    Ribelli, Giulia
    Santoni, Matteo
    Vincenzi, Bruno
    Tonini, Giuseppe
    Santini, Daniele
    EXPERT OPINION ON EMERGING DRUGS, 2015, 20 (04) : 637 - 651
  • [39] Epilepsy in brain metastasis: an emerging entity
    Roberta Rudà
    Francesca Mo
    Alessia Pellerino
    Current Treatment Options in Neurology, 2020, 22
  • [40] Drosophila as an emerging model to study metastasis
    Madhuri Kango-Singh
    Georg Halder
    Genome Biology, 5
12345