Copper(I)-catalyzed synthesis of isoindolo[1,2-b]quinazoline derivatives via an α-arylation under Pd and ligand free conditions

被引：1

作者：

Zhang, Yan ^{[1
]}

Liu, Jian-Quan ^{[1
]}

Wang, Xiang-Shan ^{[1
]}

机构：

[1] Jiangsu Normal Univ, Sch Chem & Chem Engn, Jiangsu Key Lab Green Synth Funct Mat, Xuzhou 221116, Jiangsu, Peoples R China

来源：

TETRAHEDRON LETTERS | 2020年 / 61卷 / 46期

关键词：

Isoindoloquinazoline; alpha-Arylation reaction; CuI; Pd-free; NUCLEOPHILIC AROMATIC-SUBSTITUTION; EFFICIENT SYNTHESIS; HIGHLY EFFICIENT; QUINAZOLINONES; ANNULATION; HYDROAMINATION; ISOCYANIDE; COMPLEXES; BROMIDES; DESIGN;

D O I：

10.1016/j.tetlet.2020.152508

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A tandem cyclization reaction of diethyl 2-(2-aminobenzamido)malonates and 2-bromobenzaldehydes was developed for the synthesis of isoindolo[1,2-b]quinazoline derivatives. The quinazoline was formed first catalyzed by CuI, followed by a noteworthy alpha-arylation reaction under Pd and ligand-free conditions in the presence of Cs2CO3. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页数：4

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