Copper(I)-catalyzed synthesis of isoindolo[1,2-b]quinazoline derivatives via an α-arylation under Pd and ligand free conditions

被引：1
|
作者：
Zhang, Yan [1 ]
Liu, Jian-Quan [1 ]
Wang, Xiang-Shan [1 ]
机构：
[1] Jiangsu Normal Univ, Sch Chem & Chem Engn, Jiangsu Key Lab Green Synth Funct Mat, Xuzhou 221116, Jiangsu, Peoples R China
来源：
TETRAHEDRON LETTERS | 2020年 / 61卷 / 46期
关键词：
Isoindoloquinazoline; alpha-Arylation reaction; CuI; Pd-free; NUCLEOPHILIC AROMATIC-SUBSTITUTION; EFFICIENT SYNTHESIS; HIGHLY EFFICIENT; QUINAZOLINONES; ANNULATION; HYDROAMINATION; ISOCYANIDE; COMPLEXES; BROMIDES; DESIGN;
D O I：
10.1016/j.tetlet.2020.152508
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A tandem cyclization reaction of diethyl 2-(2-aminobenzamido)malonates and 2-bromobenzaldehydes was developed for the synthesis of isoindolo[1,2-b]quinazoline derivatives. The quinazoline was formed first catalyzed by CuI, followed by a noteworthy alpha-arylation reaction under Pd and ligand-free conditions in the presence of Cs2CO3. (C) 2020 Elsevier Ltd. All rights reserved.
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页数：4
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