Sonochemical FeF3 catalyzed three-component synthesis of densely functionalized tetrahydroindazolo[3,2-b]quinazoline under solvent free conditions

A green and efficient procedure has been developed for the synthesis of densely functionalized tetrahydroindazolo[3,2-b]quinazoline catalyzed by iron fluoride under sonication in solvent-free condition. In comparison to the conventional methods, this efficient green protocol provides remarkable advantages such as good to excellent yields, shorter reaction time, low cost, easy work-up procedure, and bypass for use of solvent and column chromatography. One of the important and interesting advantages of this methodology compared to previous method is that acyclic 1,3-dicarbonyl also gives the desired product which was not possible using the previously reported methodologies. (C) 2016 Elsevier Ltd. All rights reserved.