FGF20 and Parkinson's Disease: No Evidence of Association or Pathogenicity via α-Synuclein Expression

被引：39

作者：

Wider, Christian ^{[1
,2
]}

Dachsel, Justus C.

Soto, Alexandra I.

Heckman, Michael G.

Diehl, Nancy N.

Yue, Mei

Lincoln, Sarah

Aasly, Jan O. ^{[3
,4
]}

Haugarvoll, Kristoffer ^{[3
]}

Trojanowski, John Q. ^{[5
]}

Papapetropoulos, Spiridon ^{[6
]}

Mash, Deborah ^{[6
]}

Rajput, Alex ^{[7
]}

Rajput, Ali H. ^{[7
]}

Gibson, J. Mark ^{[8
]}

Lynch, Timothy ^{[9
,10
]}

Dickson, Dennis W. ^{[11
]}

Uitti, Ryan J. ^{[2
]}

Wszolek, Zbigniew K. ^{[2
]}

Farrer, Matthew J.

Ross, Owen A.

机构：

[1] Mayo Clin, Dept Neurosci, Morris K Udall Parkinsons Dis Res Ctr Excellence, Jacksonville, FL 32224 USA

[2] Mayo Clin, Dept Neurol, Jacksonville, FL 32224 USA

[3] Norwegian Univ Sci & Technol, Dept Neurosci, N-7034 Trondheim, Norway

[4] St Olavs Hosp, Dept Neurol, Trondheim, Norway

[5] Univ Penn, Sch Med, Dept Pathol, Philadelphia, PA 19104 USA

[6] Univ Miami, Sch Med, Dept Pathol, Miami, FL USA

[7] Univ Saskatchewan, Royal Univ Hosp, Div Neurol, Saskatoon, SK, Canada

[8] Royal Victoria Hosp, Dept Neurol, Belfast BT12 6BA, Antrim, North Ireland

[9] Mater Misericordiae Univ Hosp, Dept Neurol, Dublin 7, Ireland

[10] Univ Coll Dublin Conway Neurosci Investigator, Dublin, Ireland

[11] Mayo Clin, Dept Neuropathol, Jacksonville, FL 32224 USA

来源：

MOVEMENT DISORDERS | 2009年 / 24卷 / 03期

基金：

瑞士国家科学基金会;

关键词：

Parkinson's disease; FGF20; alpha-synuclein; association study; genetics; LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; RISK; HAPLOTYPES;

D O I：

10.1002/mds.22442

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Genetic variation in fibroblast growth factor 20 (FGF20) has been associated with risk of Parkinson's disease (PD). Functional evidence suggested the T allele of one SNP, rs12720208 C/T, altered PD risk by increasing FGF20 and alpha-synuclein protein levels. Herein we report our association study of FGF20 and PD risk in four patient-control series (total: 1,262 patients and 1,881 controls), and measurements of FGF20 and alpha-synuclein protein levels in brain samples (nine patients). We found no evidence of association between FGF20 variability and PD risk, and no relationship between the rs12720208 genotype, FGF20 and alpha-synuclein protein levels. (C) 2009 Movement Disorder Society

引用

页码：455 / 459

页数：5

共 50 条

[41] α-synuclein and Parkinson's Disease
Recchia, A
Debetto, P
Negro, A
Guidolin, D
Skaper, SD
Giusti, P
FASEB JOURNAL, 2004, 18 (06): : 617 - 626
[42] α-synuclein and Parkinson's disease
Golbe, LI
PARKINSON'S DISEASE, 2003, 91 : 165 - 174
[43] Mutation, sequence analysis, and association studies of α-synuclein in Parkinson's disease
Parsian, A
Racette, B
Zhang, ZH
Chakraverty, S
Rundle, M
Goate, A
Perlmutter, JS
NEUROLOGY, 1998, 51 (06) : 1757 - 1759
[44] Quantitative assessment of the effect of FGF20 rs1721100 and rs12720208 variant on the risk of sporadic Parkinson's disease: a meta-analysis
Quan, Wei
Li, Jia
Liu, Li
Zhang, Qinghui
Qin, Yidan
Pei, Xiaochen
Chen, Jiajun
NEUROLOGICAL SCIENCES, 2022, 43 (05) : 3145 - 3152
[45] Quantitative assessment of the effect of FGF20 rs1721100 and rs12720208 variant on the risk of sporadic Parkinson’s disease: a meta-analysis
Wei Quan
Jia Li
Li Liu
Qinghui Zhang
Yidan Qin
Xiaochen Pei
Jiajun Chen
Neurological Sciences, 2022, 43 : 3145 - 3152
[46] β-Synuclein Intermediates α-Synuclein Neurotoxicity in Parkinson's Disease
Xian, Meiyan
Li, Jingwen
Liu, Tingting
Hou, Kaiying
Sun, Lin
Wei, Jianshe
ACS CHEMICAL NEUROSCIENCE, 2024, 15 (13): : 2445 - 2453
[47] Cofilin 1 promotes the pathogenicity and transmission of pathological α-synuclein in mouse models of Parkinson’s disease
Mingmin Yan
Min Xiong
Lijun Dai
Xingyu Zhang
Yunhong Zha
Xiaorong Deng
Zhui Yu
Zhentao Zhang
npj Parkinson's Disease, 8
[48] Cofilin 1 promotes the pathogenicity and transmission of pathological α-synuclein in mouse models of Parkinson's disease
Yan, Mingmin
Xiong, Min
Dai, Lijun
Zhang, Xingyu
Zha, Yunhong
Deng, Xiaorong
Yu, Zhui
Zhang, Zhentao
NPJ PARKINSONS DISEASE, 2022, 8 (01)
[49] Expression of α-synuclein, a protein involved in Parkinson's disease, in the retina of vertebrates
Martín-Neto, J
Martínez-Navarrete, GC
Angulo, A
Herrero, MT
Cuenca, N
FEBS JOURNAL, 2005, 272 : 443 - 443
[50] Alpha synuclein and crystallin expression in human lens in Parkinson's disease
Schneider, S. A.
Richert, E.
Kuhlenbaeumer, G.
Noelle, B.
Bhatia, K. P.
Deuschl, G.
Roider, J.
Klettner, A.
MOVEMENT DISORDERS, 2016, 31 : S266 - S266

← 1 2 3 4 5 →