FGF20 and Parkinson's Disease: No Evidence of Association or Pathogenicity via α-Synuclein Expression

被引：39
|
作者：
Wider, Christian [1 ,2 ]
Dachsel, Justus C.
Soto, Alexandra I.
Heckman, Michael G.
Diehl, Nancy N.
Yue, Mei
Lincoln, Sarah
Aasly, Jan O. [3 ,4 ]
Haugarvoll, Kristoffer [3 ]
Trojanowski, John Q. [5 ]
Papapetropoulos, Spiridon [6 ]
Mash, Deborah [6 ]
Rajput, Alex [7 ]
Rajput, Ali H. [7 ]
Gibson, J. Mark [8 ]
Lynch, Timothy [9 ,10 ]
Dickson, Dennis W. [11 ]
Uitti, Ryan J. [2 ]
Wszolek, Zbigniew K. [2 ]
Farrer, Matthew J.
Ross, Owen A.
机构：
[1] Mayo Clin, Dept Neurosci, Morris K Udall Parkinsons Dis Res Ctr Excellence, Jacksonville, FL 32224 USA
[2] Mayo Clin, Dept Neurol, Jacksonville, FL 32224 USA
[3] Norwegian Univ Sci & Technol, Dept Neurosci, N-7034 Trondheim, Norway
[4] St Olavs Hosp, Dept Neurol, Trondheim, Norway
[5] Univ Penn, Sch Med, Dept Pathol, Philadelphia, PA 19104 USA
[6] Univ Miami, Sch Med, Dept Pathol, Miami, FL USA
[7] Univ Saskatchewan, Royal Univ Hosp, Div Neurol, Saskatoon, SK, Canada
[8] Royal Victoria Hosp, Dept Neurol, Belfast BT12 6BA, Antrim, North Ireland
[9] Mater Misericordiae Univ Hosp, Dept Neurol, Dublin 7, Ireland
[10] Univ Coll Dublin Conway Neurosci Investigator, Dublin, Ireland
[11] Mayo Clin, Dept Neuropathol, Jacksonville, FL 32224 USA
来源：
MOVEMENT DISORDERS | 2009年 / 24卷 / 03期
基金：
瑞士国家科学基金会;
关键词：
Parkinson's disease; FGF20; alpha-synuclein; association study; genetics; LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; RISK; HAPLOTYPES;
D O I：
10.1002/mds.22442
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Genetic variation in fibroblast growth factor 20 (FGF20) has been associated with risk of Parkinson's disease (PD). Functional evidence suggested the T allele of one SNP, rs12720208 C/T, altered PD risk by increasing FGF20 and alpha-synuclein protein levels. Herein we report our association study of FGF20 and PD risk in four patient-control series (total: 1,262 patients and 1,881 controls), and measurements of FGF20 and alpha-synuclein protein levels in brain samples (nine patients). We found no evidence of association between FGF20 variability and PD risk, and no relationship between the rs12720208 genotype, FGF20 and alpha-synuclein protein levels. (C) 2009 Movement Disorder Society
引用
收藏
页码：455 / 459
页数：5
相关论文
共 50 条
  • [21] Polymorphisms of the α-synuclein promoter: expression analyses and association studies in Parkinson's disease
    C. Holzmann
    R. Krüger
    A. M. M. Vieira Saecker
    I. Schmitt
    L. Schöls
    K. Berger
    O. Riess
    Journal of Neural Transmission, 2003, 110 : 67 - 76
  • [22] Polymorphisms of the α-synuclein promoter:: expression analyses and association studies in Parkinson's disease
    Holzmann, C
    Krüger, R
    Saecker, AMMV
    Schmitt, I
    Schöls, L
    Berger, K
    Riess, O
    JOURNAL OF NEURAL TRANSMISSION, 2003, 110 (01) : 67 - 76
  • [23] Expression of α-synuclein mRNA in Parkinson's disease
    Papapetropoulos, Spiridon
    Shehadeh, Lina
    Shehadeh, Lina
    MOVEMENT DISORDERS, 2007, 22 (07) : 1057 - 1059
  • [24] Quantitative assessment of the effect of FGF20 rs12720208 variant on the risk of Parkinson's disease: a meta-analysis
    Wang, Xiaoli
    Sun, Xiaoxuan
    Zhang, Xiaona
    Li, Hong
    Xie, Anmu
    NEUROLOGICAL RESEARCH, 2017, 39 (04) : 374 - 380
  • [25] Association of α-synuclein gene haplotypes with Parkinson's disease
    Parsian, A. J.
    Racette, B. A.
    Zhao, J. H.
    Sinha, R.
    Patra, B.
    Perlmutter, J. S.
    Parsian, A.
    PARKINSONISM & RELATED DISORDERS, 2007, 13 (06) : 343 - 347
  • [26] Analysis of the rs12720208 single-nucleotide polymorphism of the FGF20 gene in Russian patients with sporadic Parkinson’s disease
    V. V. Ustinova
    M. I. Shadrina
    E. Yu. Fedotova
    S. N. Illarioshkin
    S. A. Limborska
    P. A. Slominsky
    Russian Journal of Genetics, 2012, 48 : 1257 - 1259
  • [27] Analysis of the rs12720208 single-nucleotide polymorphism of the FGF20 gene in Russian patients with sporadic Parkinson's disease
    Ustinova, V. V.
    Shadrina, M. I.
    Fedotova, E. Yu.
    Illarioshkin, S. N.
    Limborska, S. A.
    Slominsky, P. A.
    RUSSIAN JOURNAL OF GENETICS, 2012, 48 (12) : 1257 - 1259
  • [28] Alteration in α-synuclein mRNA expression in Parkinson's disease
    Kingsbury, AE
    Daniel, SE
    Sangha, H
    Eisen, S
    Lees, AJ
    Foster, OJF
    MOVEMENT DISORDERS, 2004, 19 (02) : 162 - 170
  • [29] Expression of gamma-synuclein in Parkinson's disease
    Slonimsky, A.
    Hickey, L.
    Christian, L.
    Dexter, D. T.
    Pearce, R. K. B.
    Graeber, M. B.
    Moran, L. B.
    NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2007, 33 (02) : 256 - 256
  • [30] Regulation of α-synuclein expression:: Implications for Parkinson's disease
    Chiba-Falek, O
    Nussbaum, RL
    COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 2003, 68 : 409 - 415
12345