FGF20 and Parkinson's Disease: No Evidence of Association or Pathogenicity via α-Synuclein Expression

被引：39

作者：

Wider, Christian ^{[1
,2
]}

Dachsel, Justus C.

Soto, Alexandra I.

Heckman, Michael G.

Diehl, Nancy N.

Yue, Mei

Lincoln, Sarah

Aasly, Jan O. ^{[3
,4
]}

Haugarvoll, Kristoffer ^{[3
]}

Trojanowski, John Q. ^{[5
]}

Papapetropoulos, Spiridon ^{[6
]}

Mash, Deborah ^{[6
]}

Rajput, Alex ^{[7
]}

Rajput, Ali H. ^{[7
]}

Gibson, J. Mark ^{[8
]}

Lynch, Timothy ^{[9
,10
]}

Dickson, Dennis W. ^{[11
]}

Uitti, Ryan J. ^{[2
]}

Wszolek, Zbigniew K. ^{[2
]}

Farrer, Matthew J.

Ross, Owen A.

机构：

[1] Mayo Clin, Dept Neurosci, Morris K Udall Parkinsons Dis Res Ctr Excellence, Jacksonville, FL 32224 USA

[2] Mayo Clin, Dept Neurol, Jacksonville, FL 32224 USA

[3] Norwegian Univ Sci & Technol, Dept Neurosci, N-7034 Trondheim, Norway

[4] St Olavs Hosp, Dept Neurol, Trondheim, Norway

[5] Univ Penn, Sch Med, Dept Pathol, Philadelphia, PA 19104 USA

[6] Univ Miami, Sch Med, Dept Pathol, Miami, FL USA

[7] Univ Saskatchewan, Royal Univ Hosp, Div Neurol, Saskatoon, SK, Canada

[8] Royal Victoria Hosp, Dept Neurol, Belfast BT12 6BA, Antrim, North Ireland

[9] Mater Misericordiae Univ Hosp, Dept Neurol, Dublin 7, Ireland

[10] Univ Coll Dublin Conway Neurosci Investigator, Dublin, Ireland

[11] Mayo Clin, Dept Neuropathol, Jacksonville, FL 32224 USA

来源：

MOVEMENT DISORDERS | 2009年 / 24卷 / 03期

基金：

瑞士国家科学基金会;

关键词：

Parkinson's disease; FGF20; alpha-synuclein; association study; genetics; LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; RISK; HAPLOTYPES;

D O I：

10.1002/mds.22442

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Genetic variation in fibroblast growth factor 20 (FGF20) has been associated with risk of Parkinson's disease (PD). Functional evidence suggested the T allele of one SNP, rs12720208 C/T, altered PD risk by increasing FGF20 and alpha-synuclein protein levels. Herein we report our association study of FGF20 and PD risk in four patient-control series (total: 1,262 patients and 1,881 controls), and measurements of FGF20 and alpha-synuclein protein levels in brain samples (nine patients). We found no evidence of association between FGF20 variability and PD risk, and no relationship between the rs12720208 genotype, FGF20 and alpha-synuclein protein levels. (C) 2009 Movement Disorder Society

引用

页码：455 / 459

页数：5

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