Dasatinib Inhibits FLT3/ITD and PTPN11mutated Acute Myeloid Leukemia Cells Overexpressing SRC Tyrosine Kinases

被引：0
|
作者：
Tavor, Sigal [1 ]
Shalit, Tali [2 ]
Ilani, Noa Chapal [3 ]
Moskovitz, Yoni [3 ]
Livnat, Nir [2 ]
Groner, Yoram [2 ]
Bar, Haim [2 ]
Plotnikov, Alexander [2 ]
Kaushansky, Nathali [3 ]
Shlush, Liran I. [3 ]
机构：
[1] Assuta Med Ctr, Hematooncol, Tel Aviv, Israel
[2] Weizmann Inst Sci, Rehovot, Israel
[3] Weizmann Inst Sci, Dept Immunol, Rehovot, Israel
来源：
BLOOD | 2019年 / 134卷
关键词：
D O I：
10.1182/blood-2019-128016
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
1451
引用
收藏
页数：4
相关论文
共 50 条
  • [21] Acute myeloid leukemia with NPM1 and FLT3 ITD mimicking acute promyelocytic leukemia
    Pepper, Michael
    Tan, Brent
    BLOOD, 2020, 136 (12) : 1467 - 1467
  • [22] Arsenic trioxide induces autophagic degradation of the FLT3-ITD mutated protein in FLT3-ITD acute myeloid leukemia cells
    Liu, Xiao-Jian
    Wang, Li-Na
    Zhang, Zu-Han
    Liang, Cong
    Li, Yu
    Luo, Jie-Si
    Peng, Chun-Jin
    Zhang, Xiao-Li
    Ke, Zhi-Yong
    Huang, Li-Bin
    Tang, Yan-Lai
    Luo, Xue-Qun
    JOURNAL OF CANCER, 2020, 11 (12): : 3476 - 3482
  • [23] Synergistic Effect of SGN-CD33A and FLT3 Inhibitors in FLT3/ITD Acute Myeloid Leukemia
    Tarlock, Katherine
    Thurman, Robert
    Rohm, Rory
    Biechele, Travis
    Arthur, Bill
    Meshinchi, Soheil
    BLOOD, 2018, 132
  • [24] CABOZANTINIB IS SELECTIVELY CYTOTOXIC IN ACUTE MYELOID LEUKEMIA CELLS WITH INTERNAL TANDEM DUPLICATION OF FLT3 (FLT3-ITD)
    Wang, A.
    Lu, J. W.
    Hou, H. A.
    Chen, C. Y.
    Hu, C. Y.
    Ou, D. L.
    Ko, Y. C.
    Tien, H. F.
    Lin, L. I.
    HAEMATOLOGICA, 2014, 99 : 291 - 291
  • [25] Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia
    Genevra Pillinger
    Amina Abdul-Aziz
    Lyubov Zaitseva
    Matthew Lawes
    David J. MacEwan
    Kristian M. Bowles
    Stuart A. Rushworth
    Scientific Reports, 5
  • [26] Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia
    Pillinger, Genevra
    Abdul-Aziz, Amina
    Zaitseva, Lyubov
    Lawes, Matthew
    MacEwan, David J.
    Bowles, Kristian M.
    Rushworth, Stuart A.
    SCIENTIFIC REPORTS, 2015, 5
  • [27] OTS167 Inhibits FLT3 Expression in FLT3 Mutant Acute Myeloid Leukemia
    Eisfelder, Bartholomew
    Wynne, Joseph
    Colton, Margert
    Cheng, Jason
    Odenike, Olatoyosi
    Alachkar, Houda
    Stock, Wendy
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2019, 19 : S239 - S240
  • [28] Dual inhibition of Fes and Flt3 tyrosine kinases potently inhibits Flt3-ITD+ AML cell growth
    Weir, Mark C.
    Hellwig, Sabine
    Tan, Li
    Liu, Yao
    Gray, Nathanael S.
    Smithgall, Thomas E.
    PLOS ONE, 2017, 12 (07):
  • [29] Higher daunorubicin exposure benefits FLT3 mutated acute myeloid leukemia
    Burnett, Alan K.
    Russell, Nigel H.
    Hills, Robert K.
    BLOOD, 2016, 128 (03) : 449 - 452
  • [30] Practical tips for managing FLT3 mutated acute myeloid leukemia with midostaurin
    Arnan Sangerman, Montserrat
    Fernandez Moreno, Ainhoa
    Garcia Quintana, Antonio
    Garcia-Vidal, Carolina
    Olave Rubio, Maria Teresa
    Tormo Diaz, Maria Del Mar
    Vendranas, Meritxell
    Rodriguez Macias, Gabriela
    EXPERT REVIEW OF HEMATOLOGY, 2022, 15 (03) : 203 - 214
12345